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Inducing Quality Immune Response to Respiratory Viruses May Not Be a Simple Task


Affiliations
1 HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur (PO), Bengaluru 560 064, India
 

A few front-runner vaccines for COVID-19 have reported over 90% protection in phase II/III clinical trials, raising hopes. These studies, however, have evaluated only a relative, not absolute, protection. The leading COVID-19 vaccines have been designed to elicit a systemic, not mucosal, immune response. While a systemic immune response may reduce disease severity, only the mucosal immune response can reduce the spreading of a respiratory viral infection. Here, we explain why inducing long-lasting and high-quality immune response to mucosal infections is typically challenging. A few possible solutions are proposed.

Keywords

COVID-19 Vaccines, Clinical Trials, Respiratory Viral Infection, Systemic and Mucosal Immune Response.
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  • Inducing Quality Immune Response to Respiratory Viruses May Not Be a Simple Task

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Authors

Udaykumar Ranga
HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur (PO), Bengaluru 560 064, India
Mangaiarkarasi Asokan
HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur (PO), Bengaluru 560 064, India

Abstract


A few front-runner vaccines for COVID-19 have reported over 90% protection in phase II/III clinical trials, raising hopes. These studies, however, have evaluated only a relative, not absolute, protection. The leading COVID-19 vaccines have been designed to elicit a systemic, not mucosal, immune response. While a systemic immune response may reduce disease severity, only the mucosal immune response can reduce the spreading of a respiratory viral infection. Here, we explain why inducing long-lasting and high-quality immune response to mucosal infections is typically challenging. A few possible solutions are proposed.

Keywords


COVID-19 Vaccines, Clinical Trials, Respiratory Viral Infection, Systemic and Mucosal Immune Response.

References





DOI: https://doi.org/10.18520/cs%2Fv120%2Fi8%2F1315-1323