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Crumbs Top and ‘Notch’ed Bottom in Tumours


Affiliations
1 Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine, New Brunswick, Saint John, NB, E2L4L5, Canada
2 Chemical Biology Laboratory, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
3 Department of Biochemistry, Central University of Haryana, Mahendergarh 123 029, India
 

Membrane-bound proteins integrate and coordinate various signalling activities to maintain tissue architecture. In recent years, research updates indicate that these proteins undergo post-translational modification like glycosylation to maintain tissue integrity. Here we discuss research updates from Drosophila, about two essential membrane-bound proteins, Notch and Crumbs, that undergo such modifications to interact with each other and their implications in tumorigenesis

Keywords

Epidermal-Growth-Factor Repeats, Glycosyltransferases, Membrane-Bound Proteins, Tumorigenesis, Xylosylation.
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  • Crumbs Top and ‘Notch’ed Bottom in Tumours

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Authors

Shanmugasundaram Pakkiriswami
Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine, New Brunswick, Saint John, NB, E2L4L5, Canada
Sampath Natarajan
Chemical Biology Laboratory, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
Usha Nagarajan
Department of Biochemistry, Central University of Haryana, Mahendergarh 123 029, India

Abstract


Membrane-bound proteins integrate and coordinate various signalling activities to maintain tissue architecture. In recent years, research updates indicate that these proteins undergo post-translational modification like glycosylation to maintain tissue integrity. Here we discuss research updates from Drosophila, about two essential membrane-bound proteins, Notch and Crumbs, that undergo such modifications to interact with each other and their implications in tumorigenesis

Keywords


Epidermal-Growth-Factor Repeats, Glycosyltransferases, Membrane-Bound Proteins, Tumorigenesis, Xylosylation.

References





DOI: https://doi.org/10.18520/cs%2Fv121%2Fi10%2F1297-1301