Current Science

Open Access Open Access  Restricted Access Subscription Access

Evaluation of deep eutectic solvents as a potential non-aqueous medium for the efficient dissolution and biomaterial preparation of ε-poly-l-lysine


Affiliations
1 Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India
2 Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India; Academy of Scientific and Innovative Research, Ghaziabad 212 001, India

e-Poly-l-lysine (e-PLL) extracted from Streptomyces albulus was solubilized and analysed for its structural as well as chemical stability in several deep eutectic solvents (DESs). The DES synthesized was composed of urea (hydrogen-bond donor) and choline chloride (hydro­gen-bond acceptor) in the molar ratio 2 : 1. Furthermore, it formed a soft ionogel (gel strength: 177 g cm–2) in the presence of 20% w/v e-PLL at room temperature in about 10–15 days. However, such gelation was not observed at lower concentrations (5%, 10% and 15% w/v) of the homopolypeptide. Regenerated e-PLL from DES was examined, and it was found to maintain its structural and chemical stability during the dissolution process.

Keywords

Deep eutectic solvents, gelation, non-aqueous medium, ε-poly-L-lysine, Streptomyces albulus, structural and chemical stability.
User
Notifications
Font Size

Abstract Views: 24




  • Evaluation of deep eutectic solvents as a potential non-aqueous medium for the efficient dissolution and biomaterial preparation of ε-poly-l-lysine

Abstract Views: 24  | 

Authors

Nishith A. Chudasama
Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India
Rosy Sequeira
Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India; Academy of Scientific and Innovative Research, Ghaziabad 212 001, India
Tapan Kumar Maity
Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India; Academy of Scientific and Innovative Research, Ghaziabad 212 001, India
Kamalesh Prasad
Natural Products and Green Chemistry Division, CSIR-Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar 364 002, India; Academy of Scientific and Innovative Research, Ghaziabad 212 001, India

Abstract


e-Poly-l-lysine (e-PLL) extracted from Streptomyces albulus was solubilized and analysed for its structural as well as chemical stability in several deep eutectic solvents (DESs). The DES synthesized was composed of urea (hydrogen-bond donor) and choline chloride (hydro­gen-bond acceptor) in the molar ratio 2 : 1. Furthermore, it formed a soft ionogel (gel strength: 177 g cm–2) in the presence of 20% w/v e-PLL at room temperature in about 10–15 days. However, such gelation was not observed at lower concentrations (5%, 10% and 15% w/v) of the homopolypeptide. Regenerated e-PLL from DES was examined, and it was found to maintain its structural and chemical stability during the dissolution process.

Keywords


Deep eutectic solvents, gelation, non-aqueous medium, ε-poly-L-lysine, Streptomyces albulus, structural and chemical stability.



DOI: https://doi.org/10.18520/cs%2Fv125%2Fi12%2F1328-1333