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The Influence of Type-2 Diabetes on Cataract and their Shared Genetic Basis Through Relevant Genome-wide Association Studies


Affiliations
1 Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, University of Madras, Chennai 603 103, India
2 Dr Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai 600 086, India

Cataract in type-2 diabetes (T2D) patients is a secondary complication and one of the leading causes of vision loss next to diabetic retinopathy. Various factors such as age, gender, diabetes duration, HbA1c, BMI and gene­tics contribute towards cataractogenesis. The genetic predisposition of patients with T2D to develop cataract remains unanswered. It is important to examine the underlying genetic etiology of cataract in T2D through large-scale genetic studies. Since there have been only a handful of genome-wide association studies (GWAS) on T2D-influenced cataract, multiple studies from various ethnicities are warranted to substantiate if T2D truly influences the development of cataract. This study provides an overview of possible mechanisms and factors that trigger the development of cataract in T2D patients, relevant GWAS and the role of genes associated with T2D-associated cataract.

Keywords

Aldose reductase, diabetic cataract, genomewide association studies, polygenic risk score, sorbitol dehydrogenase
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  • The Influence of Type-2 Diabetes on Cataract and their Shared Genetic Basis Through Relevant Genome-wide Association Studies

Abstract Views: 145  | 

Authors

Janaki Sneha
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, University of Madras, Chennai 603 103, India
Saravanan Yogaprabhu
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, University of Madras, Chennai 603 103, India
Ranjit Mohan Anjana
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, University of Madras, Chennai 603 103, India
Viswanathan Mohan
Dr Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Excellence in Diabetes Care, Chennai 600 086, India
Venkatesan Radha
Madras Diabetes Research Foundation, ICMR Centre for Advanced Research on Diabetes, University of Madras, Chennai 603 103, India

Abstract


Cataract in type-2 diabetes (T2D) patients is a secondary complication and one of the leading causes of vision loss next to diabetic retinopathy. Various factors such as age, gender, diabetes duration, HbA1c, BMI and gene­tics contribute towards cataractogenesis. The genetic predisposition of patients with T2D to develop cataract remains unanswered. It is important to examine the underlying genetic etiology of cataract in T2D through large-scale genetic studies. Since there have been only a handful of genome-wide association studies (GWAS) on T2D-influenced cataract, multiple studies from various ethnicities are warranted to substantiate if T2D truly influences the development of cataract. This study provides an overview of possible mechanisms and factors that trigger the development of cataract in T2D patients, relevant GWAS and the role of genes associated with T2D-associated cataract.

Keywords


Aldose reductase, diabetic cataract, genomewide association studies, polygenic risk score, sorbitol dehydrogenase



DOI: https://doi.org/10.18520/cs%2Fv126%2Fi3%2F320-325