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Analysis of Morphological Changes in Erythrocytes in Malaria by Shape Descriptors Prior to and After Antimalarial Drugs


Affiliations
1 School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore 632 014, India, India
2 School of Electronics Engineering, Vellore Institute of Technology, Vellore 632 014, India
3 Center for Biomedical Engineering, S.G.N.E. Foundation, 3rd Street Park Avenue, Chennai 600 042, India

In this study, malarial patients (n = 80) were treated for three days with artesunate and amodiaquine (ASAQ). Twenty healthy individuals in a similar age range were chosen as the control group. The contours of the erythrocytes were extracted from the processed microscopic images, and the shape parameters were derived from them. The erythrocytes were scanned along their largest diameter to determine the variation in grey-level intensity. The results showed that the change in shape parameters and grey-level intensity was similar to normal on day 4 after treatment. This provides novel insights into the contribution of ASAQ to the recovery of erythrocytes.

Keywords

Antimalarial drugs, erythrocytes, grey-level intensity, Plasmodium falciparum malaria, shape descriptors
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  • Analysis of Morphological Changes in Erythrocytes in Malaria by Shape Descriptors Prior to and After Antimalarial Drugs

Abstract Views: 149  | 

Authors

Maombi Edison
School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore 632 014, India, India
J. B. Jeeva
School of Electronics Engineering, Vellore Institute of Technology, Vellore 632 014, India
Megha Singh
Center for Biomedical Engineering, S.G.N.E. Foundation, 3rd Street Park Avenue, Chennai 600 042, India

Abstract


In this study, malarial patients (n = 80) were treated for three days with artesunate and amodiaquine (ASAQ). Twenty healthy individuals in a similar age range were chosen as the control group. The contours of the erythrocytes were extracted from the processed microscopic images, and the shape parameters were derived from them. The erythrocytes were scanned along their largest diameter to determine the variation in grey-level intensity. The results showed that the change in shape parameters and grey-level intensity was similar to normal on day 4 after treatment. This provides novel insights into the contribution of ASAQ to the recovery of erythrocytes.

Keywords


Antimalarial drugs, erythrocytes, grey-level intensity, Plasmodium falciparum malaria, shape descriptors



DOI: https://doi.org/10.18520/cs%2Fv126%2Fi5%2F555-561