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Understanding the Influence of Diabetes on Wound Healing and Exploring Effective Management Study


Affiliations
1 Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
2 Department of Biotechnology, Noida Institute of Engineering and Technology, Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
3 Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144 001, India

Diabetes is a diverse metabolic disease that is caused by increased levels of blood glucose, which also leads to the generation of several other complications. The formation of wounds and their delayed healing are among the main areas of concern. Wound repair is a process, which replaces damaged cells with healthy cells; it generally occurs in four steps – haemostasis, inflammation, proliferation and remodelling. This review covers the causes of diabetes mellitus, its prevalence, its impact on wound healing, different types of wounds and their management. Diabetes mellitus impairs wound healing through several mechanisms such as impaired angiogenesis, altered collagen production, etc.

Keywords

Angiogenesis, collagen, diabetes mellitus, growth factor, remodelling, ulcers, wounds.
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  • Understanding the Influence of Diabetes on Wound Healing and Exploring Effective Management Study

Abstract Views: 232  | 

Authors

Deepraj Singh Rautela
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
Saumya Das
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
Avijit Mazumder
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
Bhawana Sharma
Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
Fahad Khan
Department of Biotechnology, Noida Institute of Engineering and Technology, Plot No. 19, Knowledge Park-II, Greater Noida 201 306, India
M. V. N. L. Chaitanya
Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144 001, India

Abstract


Diabetes is a diverse metabolic disease that is caused by increased levels of blood glucose, which also leads to the generation of several other complications. The formation of wounds and their delayed healing are among the main areas of concern. Wound repair is a process, which replaces damaged cells with healthy cells; it generally occurs in four steps – haemostasis, inflammation, proliferation and remodelling. This review covers the causes of diabetes mellitus, its prevalence, its impact on wound healing, different types of wounds and their management. Diabetes mellitus impairs wound healing through several mechanisms such as impaired angiogenesis, altered collagen production, etc.

Keywords


Angiogenesis, collagen, diabetes mellitus, growth factor, remodelling, ulcers, wounds.



DOI: https://doi.org/10.18520/cs%2Fv126%2Fi12%2F1438-1445