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Advanced therapeutic approach in management of diabetes mellitus through precision medicine


Affiliations
1 Independent Researcher, Nagar Kurnool District, Telangana 509 209, India
2 Department of Food Chemistry, ICMR-National Institute of Nutrition, Hyderabad 500 007, India
3 Symbiosis Institute of Health Science, Symbiosis International (Deemed University), Pune 412 115, India
4 Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15216, United States

Among chronic diseases, diabetes mellitus carries one of the most life-threatening and disabling complications. It has its cost complications in addition to reducing life expectancy. Diabetes management aims to find each patient’s best course of action at the ideal time. Using precision medicine for patients with diabetes mellitus can improve the quality of therapy. For this, genetic screening becomes an essential component. The pharmacogenetics of antidiabetic medications can be a hallmark component that can be incorporated into genetic screening. For the management of diabetes, precision medicine is gaining momentum. Long-lasting response to oral sulphonylureas in insulin-dependent infants because of neonatal diabetes (abnormal beta cells) is considered one of the best examples of the significance of precision medicine. The present review aims to pinpoint the new subgroups of diabetes based on glutamic acid decarboxylase antibodies, age, body mass index, A1C, insulin resistance and glycemic response to metformin. Incorporating genetic screening into therapeutic therapy and achieving precision medicine for type 2 diabetes patients depends on the pharmacogenetics of anti-diabetic drugs. The importance of PM in the treatment of diabetes is expanding and its use can revolutionize the lives of diabetic individuals.

Keywords

Actionable genes, chrono nutrition, diabetes mellitus, individual intervention, omics essay, precision medicine.
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  • Advanced therapeutic approach in management of diabetes mellitus through precision medicine

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Authors

Narshima Arya
Independent Researcher, Nagar Kurnool District, Telangana 509 209, India
Tajungrenla Longkumer
Department of Food Chemistry, ICMR-National Institute of Nutrition, Hyderabad 500 007, India
Aishwarya Gandhi
Symbiosis Institute of Health Science, Symbiosis International (Deemed University), Pune 412 115, India
Srujana Medithi
Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15216, United States

Abstract


Among chronic diseases, diabetes mellitus carries one of the most life-threatening and disabling complications. It has its cost complications in addition to reducing life expectancy. Diabetes management aims to find each patient’s best course of action at the ideal time. Using precision medicine for patients with diabetes mellitus can improve the quality of therapy. For this, genetic screening becomes an essential component. The pharmacogenetics of antidiabetic medications can be a hallmark component that can be incorporated into genetic screening. For the management of diabetes, precision medicine is gaining momentum. Long-lasting response to oral sulphonylureas in insulin-dependent infants because of neonatal diabetes (abnormal beta cells) is considered one of the best examples of the significance of precision medicine. The present review aims to pinpoint the new subgroups of diabetes based on glutamic acid decarboxylase antibodies, age, body mass index, A1C, insulin resistance and glycemic response to metformin. Incorporating genetic screening into therapeutic therapy and achieving precision medicine for type 2 diabetes patients depends on the pharmacogenetics of anti-diabetic drugs. The importance of PM in the treatment of diabetes is expanding and its use can revolutionize the lives of diabetic individuals.

Keywords


Actionable genes, chrono nutrition, diabetes mellitus, individual intervention, omics essay, precision medicine.



DOI: https://doi.org/10.18520/cs%2Fv127%2Fi9%2F1029-1036