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From evolutionary relics to diabetic mellitus sentinels: a Mendelian randomization study of endogenous retrovirus group V member 1


Affiliations
1 Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China
2 Department of Hepatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
3 Institute of Immunology, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
4 Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China; Department of Hepatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China

Human endogenous retroviruses (HERVs) are retroviral elements that have integrated into the human genome during evolution and have various effects on human health and disease. Diabetic mellitus (DM) is a common metabolic disorder that affects millions of people worldwide. The causal relationship between HERVs and DM is unclear and controversial. In the present study, we used Mendelian randomization (MR) to infer the causal effect of HERV group V member 1 envelope poly­protein (HERVV-1 Env) expression on three types of DM: type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). We found that HERVV-1 Env expression had a significant protective effect on T1DM and GDM, albeit not on T2DM. The reverse MR analysis showed that the three subtypes of DM did not affect HERVV-1 Env expression. Our findings illuminate the intricate relationship between HERVV-1 Env expression and varying DM subtypes, highlighting distinct underlying mechanisms. This pioneering study into the potential causal ties between HERVs family members and DM onset offers a new perspective on the significance of HERVs in human health and pathology.

Keywords

Empirical mode decomposition, line index, multi-scale fuzzy entropy, singular value decomposition, stellar spectrum.
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  • From evolutionary relics to diabetic mellitus sentinels: a Mendelian randomization study of endogenous retrovirus group V member 1

Abstract Views: 88  | 

Authors

Mingtong Wei
Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China
Xiangyi Bu
Department of Hepatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
Anmin Wang
Institute of Immunology, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
Juanzi Gao
Department of Hepatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
Haoyuan Tan
Institute of Immunology, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
Weidong Jia
Department of General Surgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China; Department of Hepatic Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei 230001, China

Abstract


Human endogenous retroviruses (HERVs) are retroviral elements that have integrated into the human genome during evolution and have various effects on human health and disease. Diabetic mellitus (DM) is a common metabolic disorder that affects millions of people worldwide. The causal relationship between HERVs and DM is unclear and controversial. In the present study, we used Mendelian randomization (MR) to infer the causal effect of HERV group V member 1 envelope poly­protein (HERVV-1 Env) expression on three types of DM: type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). We found that HERVV-1 Env expression had a significant protective effect on T1DM and GDM, albeit not on T2DM. The reverse MR analysis showed that the three subtypes of DM did not affect HERVV-1 Env expression. Our findings illuminate the intricate relationship between HERVV-1 Env expression and varying DM subtypes, highlighting distinct underlying mechanisms. This pioneering study into the potential causal ties between HERVs family members and DM onset offers a new perspective on the significance of HERVs in human health and pathology.

Keywords


Empirical mode decomposition, line index, multi-scale fuzzy entropy, singular value decomposition, stellar spectrum.



DOI: https://doi.org/10.18520/cs%2Fv127%2Fi11%2F1310-1314