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Controversies Surrounding Coumarin in Cassia: The Good, the Bad and the not so Ugly


Affiliations
1 Indian Institute of Spices Research (ICAR), P.O. Box 1701, Marikunnu PO, Calicut 673 012, India
 

In the world and Indian market, the cinnamon available is not the true cinnamon (Cinnamomum verum), but its avatar, viz. the fake cinnamon (C. cassia). The latter contains coumarin, which at high doses, has been found to cause hepatotoxicity, carcinogenesis and liver/lung tumours in rodents. However, such ill effects in humans due to coumarin are rare and only associated with high doses. A toxicological reevaluation of coumarin aimed to derive scientifically founded maximum limits is imperative.
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  • Controversies Surrounding Coumarin in Cassia: The Good, the Bad and the not so Ugly

Abstract Views: 415  |  PDF Views: 133

Authors

R. Dinesh
Indian Institute of Spices Research (ICAR), P.O. Box 1701, Marikunnu PO, Calicut 673 012, India
N. K. Leela
Indian Institute of Spices Research (ICAR), P.O. Box 1701, Marikunnu PO, Calicut 673 012, India
T. John Zachariah
Indian Institute of Spices Research (ICAR), P.O. Box 1701, Marikunnu PO, Calicut 673 012, India
M. Anandaraj
Indian Institute of Spices Research (ICAR), P.O. Box 1701, Marikunnu PO, Calicut 673 012, India

Abstract


In the world and Indian market, the cinnamon available is not the true cinnamon (Cinnamomum verum), but its avatar, viz. the fake cinnamon (C. cassia). The latter contains coumarin, which at high doses, has been found to cause hepatotoxicity, carcinogenesis and liver/lung tumours in rodents. However, such ill effects in humans due to coumarin are rare and only associated with high doses. A toxicological reevaluation of coumarin aimed to derive scientifically founded maximum limits is imperative.


DOI: https://doi.org/10.18520/cs%2Fv108%2Fi4%2F482-484