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Association between Serum Tumour Necrosis Factor-α Concentrations and Chronic Obstructive Pulmonary Disease


Affiliations
1 Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
2 Department of Respiratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
 

Tumour necrosis factor-α (TNF-α) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted a meta-analysis to assess the association between serum TNF-α concentration and COPD. PubMed and Embase were searched for eligible studies. Data were extracted and standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Thirty-three studies were included in the meta-analysis. The serum TNF-α concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.64 pg/ml, 95%CI 0.43, 0.86). COPD patients with normal to high body mass index (BMI) and low BMI had increased TNF-α concentration compared with healthy controls (SMD = 1.14 pg/ml, 95%CI 0.36, 1.92; SMD = 1.62 pg/ml, 95%CI 0.89, 2.35 respectively). There was notable significance in serum TNF-α level between underweight and normal weight COPD patients (SMD = 0.68, 95%CI 0.43, 0.92). The meta-analysis indicates that patients with stable COPD have higher serum TNF-α concentration than healthy controls, and the higher circulating TNF-α levels in COPD patients with weight loss may suggest its valuable role in the evaluation of systemic inflammatory responses in stable COPD patients.

Keywords

Chronic Obstructive Pulmonary Disease, Meta-Analysis, Tumour Necrosis Factor-α Systemic Inflammation.
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  • Association between Serum Tumour Necrosis Factor-α Concentrations and Chronic Obstructive Pulmonary Disease

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Authors

Xiao-Feng Xiong
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Jia Wei
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Yi-Hua Lin
Department of Respiratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
De-Yun Cheng
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China

Abstract


Tumour necrosis factor-α (TNF-α) is an important pro-inflammatory cytokine and has been implicated to play a role in the systemic inflammation of patients with chronic obstructive pulmonary disease (COPD). We conducted a meta-analysis to assess the association between serum TNF-α concentration and COPD. PubMed and Embase were searched for eligible studies. Data were extracted and standard mean differences (SMDs) and 95% confidence intervals (CI) were calculated. Thirty-three studies were included in the meta-analysis. The serum TNF-α concentrations were higher in patients with stable COPD than healthy controls (SMD = 0.64 pg/ml, 95%CI 0.43, 0.86). COPD patients with normal to high body mass index (BMI) and low BMI had increased TNF-α concentration compared with healthy controls (SMD = 1.14 pg/ml, 95%CI 0.36, 1.92; SMD = 1.62 pg/ml, 95%CI 0.89, 2.35 respectively). There was notable significance in serum TNF-α level between underweight and normal weight COPD patients (SMD = 0.68, 95%CI 0.43, 0.92). The meta-analysis indicates that patients with stable COPD have higher serum TNF-α concentration than healthy controls, and the higher circulating TNF-α levels in COPD patients with weight loss may suggest its valuable role in the evaluation of systemic inflammatory responses in stable COPD patients.

Keywords


Chronic Obstructive Pulmonary Disease, Meta-Analysis, Tumour Necrosis Factor-α Systemic Inflammation.

References





DOI: https://doi.org/10.18520/cs%2Fv110%2Fi2%2F172-179