Small is the New Big - Interplay of Mirnas in Cancer

Jyotika Varshney; Subbaya Subramanian

doi:10.18520/cs/v107/i5/803-814

Small is the New Big - Interplay of Mirnas in Cancer

Affiliations
1 Department of Surgery, Division of Basic and Translational Research, and University of Minnesota, Minneapolis, MN 55455, United States

Abstract
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MicroRNAs (miRNAs) are small non-coding regulatory RNAs that post-transcriptionally regulate gene expression. About 1500 miRNAs have been discovered in humans and these can target and regulate up to 60% of coding genes. MicroRNAs play a key role in all cellular functions and are implicated in most diseases, including cancer. Deregulation of microRNA expression can affect various metabolic and signalling pathways and results in cancer development and progression. This review provides a comprehensive view of various cancer types and their associated microRNAs.