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Biology across Scales:Historical Perspective on Some Indian Contributions


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1 National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune 411 007, India
 

Understanding Biological systems across scales, has led to two apparently contradicting approaches the reductive approach, and the holistic approach. The former attempts to understand complex systems by reducing it into smaller components, whereas the latter attempts to combine information to integrate at the systems level. Many important contributions from India have been made in these areas. I attempt to present a view of these in this article to mark celebrations 30 years of the Department of Biotechnology.

Keywords

Biological Scales, Historical Perspective, Reductive and Holistic Approaches, Self-Assembly, Systems Biology.
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  • Oparin, A. I., Prioskhozhedenie Zhini Mosckovskii Rabochii, Moscow, Reprinted and translated in Bernal, J. D., The Origin of Life, Weidenfeld and Nicolson, London, 1967.
  • Haldane, J. B. S., The origin of life. Ration. Annu., 1929, 148, 3– 10.
  • Miller, S. L., A production of amino acids under possible primitive earth conditions. Science, 1953, 117, 528–529.
  • Orgel, L. E., Evolution of the genetic apparatus. J. Mol. Biol., 1968, 38, 381–393.
  • Vijayan, M., Molecular interactions and aggregation involving amino acids and peptides and their roles in chemical evolution. Prog. Biophys. Mol. Biol., 1988, 52, 71–99.
  • Gadagkar, R., Evolution of eusociality: the advantage of assured fitness returns. Philos. Trans. R. Soc. London, 1990, 329, 17–25.
  • Bagchi, B., Water dynamics in the hydration layer around proteins and micelles. Chem. Rev., 2005, 105, 3197–3219.
  • Narayan, V., Ramaswamy, S. and Menon, N., Long-lived giant number fluctuations in a swarming granular nematic. Science, 2007, 317, 105–108.
  • Haldane, J. B. S., On being the right size, 1926.
  • Wilson, E. O., On Human Nature, Harvard University Press, USA, 1978.
  • Timofeeff-Ressovky, N. W., Zimmer, K. G. and Delbruck, M., Uber die Natur der Genmutation und der Genstruktur, Nachrichten von der Gesellschaft der Wissenschaften zu Gottingen: MathematischePhysikalische Klasse, Fachgrupps VI, Biologie, 1935, pp. 189–245.
  • Schrödinger, E., What is Life? Cambridge University Press, 1944.
  • Ramachandran, G. N. and Kartha, G., Structure of collagen. Nature, 1954, 174, 269–270.
  • Ramachandran, G. N., Ramakrishnan, C. and Sasisekharan, V., Stereochemistry of polypeptide chain configurations. J. Mol. Biol., 1963, 7, 95–99.
  • De, S. N., Enterotoxicity of bacteria-free culture of Vibrio cholerae. Nature, 1959, 183, 1533–1534.
  • Kohler, R. E., Lords of the Fly: Drosophila Genetics and the Experimental Life, University of Chicago Press, USA, 1994.
  • Wood, W. B., The Nematode Caenorhabditis elegans, Cold Spring Harbor Laboratory Press, New York, 1988.
  • Siddiqi, O. H., Incorporation of parental DNA into genetic recombinants of E. coli. Proc. Natl. Acad. Sci. USA, 1963, 49, 589–592.
  • Sharma, R. P., Wingless a new mutant in Drosophila melanogaster. Drosophila Inf. Serv., 1973, 50, 134.
  • Mahalanobois, P. C., Majumdar, D. N. and Rao, C. R., Anthropometric survey of the United Provinces, 1941: a statistical study. Sankhya – Indian J. Stat., 1949, IX, 89–324.
  • Rao, C. R., Advanced Statistical Methods in Biometric Research, Oxford University Press, England, 1952, p. xii.
  • Kosambi, D. D., The estimation of map distances from recombination values. Ann. Eugen., 1943, 12, 172–175.
  • Balakrishnan, V. and Sanghvi, L. D., Distance between populations on the basis of attribute data. Biometrics, 1968, 24, 859–865.
  • Gadgil, M., Dispersal: population consequences and evolution. Ecology, 1971, 52, 253–161.

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  • Biology across Scales:Historical Perspective on Some Indian Contributions

Abstract Views: 392  |  PDF Views: 124

Authors

Shekhar C. Mande
National Centre for Cell Science, NCCS Complex, SP Pune University Campus, Ganeshkhind, Pune 411 007, India

Abstract


Understanding Biological systems across scales, has led to two apparently contradicting approaches the reductive approach, and the holistic approach. The former attempts to understand complex systems by reducing it into smaller components, whereas the latter attempts to combine information to integrate at the systems level. Many important contributions from India have been made in these areas. I attempt to present a view of these in this article to mark celebrations 30 years of the Department of Biotechnology.

Keywords


Biological Scales, Historical Perspective, Reductive and Holistic Approaches, Self-Assembly, Systems Biology.

References





DOI: https://doi.org/10.18520/cs%2Fv110%2Fi4%2F529-532