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Haematological and Immunological Response of Achyranthes aspera Leaf and Root Extracts in Arsenic-Intoxicated Female Mice (Mus musculus)


Affiliations
1 Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali 304 022, India
 

To evaluate therapeutic efficacy of Achyranthes aspera against arsenic toxicity, mice were given aqueous ischolar_main and leaf extracts at both low and high doses (100 and 200 mg/kg body wt) after being intoxicated with sodium arsenate (0.1 mg/kg body wt). Significant alterations (P < 0.05, 0.001) were seen in various haematological parameters, Ig level, macrophage yield, viability, phagocytic index and progesterone level. Results clearly depict that both A. aspera extracts significantly restore the unbalanced level up to the normal. This study shows the protective efficacy of A. aspera on altered haematological and immunological system. It is possible that future work on drug formulation may use this plant as a source.

Keywords

Achyranthes aspera, Arsenic Toxicity, Haematological Alterations, Mice Immune System.
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  • Haematological and Immunological Response of Achyranthes aspera Leaf and Root Extracts in Arsenic-Intoxicated Female Mice (Mus musculus)

Abstract Views: 416  |  PDF Views: 144

Authors

Veena Sharma
Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali 304 022, India
Rashmi Singh
Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali 304 022, India

Abstract


To evaluate therapeutic efficacy of Achyranthes aspera against arsenic toxicity, mice were given aqueous ischolar_main and leaf extracts at both low and high doses (100 and 200 mg/kg body wt) after being intoxicated with sodium arsenate (0.1 mg/kg body wt). Significant alterations (P < 0.05, 0.001) were seen in various haematological parameters, Ig level, macrophage yield, viability, phagocytic index and progesterone level. Results clearly depict that both A. aspera extracts significantly restore the unbalanced level up to the normal. This study shows the protective efficacy of A. aspera on altered haematological and immunological system. It is possible that future work on drug formulation may use this plant as a source.

Keywords


Achyranthes aspera, Arsenic Toxicity, Haematological Alterations, Mice Immune System.

References





DOI: https://doi.org/10.18520/cs%2Fv110%2Fi4%2F708-713