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Zhang, Min
- The Dnazyme Anti-insulin-like Growth Factor-IIP3 Inhibited Tumour Growth in a Mouse Model of Human Hepatocarcinoma
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Authors
Affiliations
1 Medical Department, Beihua University, Jilin 132001, CN
2 Jilin Central General Hospital, Jilin 132001, CN
1 Medical Department, Beihua University, Jilin 132001, CN
2 Jilin Central General Hospital, Jilin 132001, CN
Source
Current Science, Vol 116, No 12 (2019), Pagination: 2072-2077Abstract
Insulin-like growth factor II promoter 3 (IGF-IIP3) is the most active promoter in live cancer cells. In this study, the anti-tumour growth effects of DRz1 were measured in a model of hepatoma-bearing mice. DRz1 significantly inhibited IGF-IIP3 expression and tumour growth in vivo. Compared to the sham-treated control group, DRz1 treatment attenuated the tumour volume and weight after 14 days of treatment. DRz1 could significantly inhibit the expression of IGF-IIP3, could inhibit the associated tumour-promoting proteins and could retard the growth of hepatocarcinoma tumours in vivo. These findings provide novel evidence for the anti-tumour effects of DRz1 in vivo.Keywords
Anti-Tumour Growth, Bearing Mouse Model, Hepatocellular Carcinoma, IGF-IIP3-DRz1.Full Text
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