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Vignesh Balaji, R.
- Preparation and Characterization of PLGA-Based Biocompatible Nanoparticles for Sustained Delivery of Growth Factor for Wound Healing Applications
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Authors
Affiliations
1 Centre of Excellence for Medical Textiles, The South India Textile Research Association (SITRA), Coimbatore 641 014, IN
1 Centre of Excellence for Medical Textiles, The South India Textile Research Association (SITRA), Coimbatore 641 014, IN
Source
Current Science, Vol 115, No 7 (2018), Pagination: 1287-1296Abstract
Platelet-derived growth factor-BB (PDGF-BB) loaded PLGA : poloxamer blend nanoparticles (PLGF) were studied for their physical, chemical and biological characteristics using in vitro and in vivo experimental models. The particle size of PLGF was between 100 and 150 nm with 85% encapsulation efficiency. In vitro released kinetics revealed a slow and sustained release of growth factor (GF) for a month. Furthermore, biological studies confirmed the non-toxic, and non-irritant nature of nanoparticles and angiogenesis stimulating ability of GF released from nanoparticles demonstrating their potential for the treatment of chronic wounds in future.Keywords
PDGF-BB, PLGA, Angiogenesis, Wound Healing.Full Text
References
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