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Deciphering Unknown Proteins in Human Herpes Viruses


Affiliations
1 Ecosystem Division, National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur-440020, Maharashtra, India
     

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The Human herpes Viruses are the potential agents for causing watery blisters in the skin or mucous membranes of the mouth, lips or genitals. The complete genome sequences for various known Human herpes viruses have been done which deciphered the presence of various gene sequences for unknown proteins. We analyzed complete genome of 10 such viruses from which 3 were selected for our studies. Our attempt is to predict the structure and function of these proteins by the application of computational methods. The probable function prediction of the protein is done by using bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. While tertiary structures were constructed using PS2 Server (Protein Structure Prediction server). These studies revealed presences of enzymatic functional domain in 6 proteins; their roles are yet to be discovered in Human herpes Viruses. These data can be used for the understanding of evolutionary development of Human herpes Viruses and its life cycle during host pathogenicity.

Keywords

Unknown Proteins, Bioinformatics Web Tools, Conserved Domains, Functional Domain, Life Cycle, Host Pathogenicity.
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  • Deciphering Unknown Proteins in Human Herpes Viruses

Abstract Views: 251  |  PDF Views: 4

Authors

Swapnil Ganesh Sanmukh
Ecosystem Division, National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur-440020, Maharashtra, India
Waman Narayan Paunikar
Ecosystem Division, National Environmental Engineering Research Institute (NEERI), Nehru Marg, Nagpur-440020, Maharashtra, India

Abstract


The Human herpes Viruses are the potential agents for causing watery blisters in the skin or mucous membranes of the mouth, lips or genitals. The complete genome sequences for various known Human herpes viruses have been done which deciphered the presence of various gene sequences for unknown proteins. We analyzed complete genome of 10 such viruses from which 3 were selected for our studies. Our attempt is to predict the structure and function of these proteins by the application of computational methods. The probable function prediction of the protein is done by using bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. While tertiary structures were constructed using PS2 Server (Protein Structure Prediction server). These studies revealed presences of enzymatic functional domain in 6 proteins; their roles are yet to be discovered in Human herpes Viruses. These data can be used for the understanding of evolutionary development of Human herpes Viruses and its life cycle during host pathogenicity.

Keywords


Unknown Proteins, Bioinformatics Web Tools, Conserved Domains, Functional Domain, Life Cycle, Host Pathogenicity.



DOI: https://doi.org/10.36039/ciitaas%2F4%2F5%2F2012%2F106875.161-165