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The Study of the Presence of Monoterpenes Constituents for the Essential Oil Extraction from Leaves


Affiliations
1 Department of Entomology, North Carolina State University, Raleigh, United States
     

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The oomycetePythiumsplendens, is a plant pathogen causing significant damage to broad spectrum of commercially and medicinally valuable plants including but not limited to black pepper, tomato, watermelon, bean etc. The pathogen disrupts the plant cell structure and its function by secreting pathogenicity related proteins that leads to infection and thereby yield loss as well as death of the plant. The most common method in practise to control these infections is the usage of chemical fungicides that are highly toxic. As an alternate, bio fungicides such as crude extracts of plants are also widely used. The inhibitory potential of the lead compound is experimentally validated through Minimum Inhibitory Concentration (MIC) assay. Lower concentrations of alliin showed maximum zone of inhibition than the chemical fungicide mancozeb. Our findings suggest that 5NNW is a promising drug target of alliin. Thus, this study confirms the antifungal property of the plant extract and the natural lead compoundto effectively combat against Pythium infections. Vascular endothelial growth factor (VEGF) is a mitogen, which plays a vital role in angiogenesis and neovascularization. Numerous medications have been developed to inhibit VEGF in cancer, because of its significance in tumor development and its survival. Hence, the current study is focused on identifying phytocompounds to directly target VEGF receptors using in-silico approach. The presence of monoterpenes as the major constituents of the essential oil extracted from leaves could be responsible for the potential antibacterial activity observed in this study.


Keywords

Pythium Splendens; NLP Protein; Chemical Fungicides; Antifungal Compounds; Molecular Docking; Minimum Inhibitory Concentration (MIC) Assay.
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  • The Study of the Presence of Monoterpenes Constituents for the Essential Oil Extraction from Leaves

Abstract Views: 252  |  PDF Views: 1

Authors

F. Lyumugabe
Department of Entomology, North Carolina State University, Raleigh, United States
R. Garcia
Department of Entomology, North Carolina State University, Raleigh, United States

Abstract


The oomycetePythiumsplendens, is a plant pathogen causing significant damage to broad spectrum of commercially and medicinally valuable plants including but not limited to black pepper, tomato, watermelon, bean etc. The pathogen disrupts the plant cell structure and its function by secreting pathogenicity related proteins that leads to infection and thereby yield loss as well as death of the plant. The most common method in practise to control these infections is the usage of chemical fungicides that are highly toxic. As an alternate, bio fungicides such as crude extracts of plants are also widely used. The inhibitory potential of the lead compound is experimentally validated through Minimum Inhibitory Concentration (MIC) assay. Lower concentrations of alliin showed maximum zone of inhibition than the chemical fungicide mancozeb. Our findings suggest that 5NNW is a promising drug target of alliin. Thus, this study confirms the antifungal property of the plant extract and the natural lead compoundto effectively combat against Pythium infections. Vascular endothelial growth factor (VEGF) is a mitogen, which plays a vital role in angiogenesis and neovascularization. Numerous medications have been developed to inhibit VEGF in cancer, because of its significance in tumor development and its survival. Hence, the current study is focused on identifying phytocompounds to directly target VEGF receptors using in-silico approach. The presence of monoterpenes as the major constituents of the essential oil extracted from leaves could be responsible for the potential antibacterial activity observed in this study.


Keywords


Pythium Splendens; NLP Protein; Chemical Fungicides; Antifungal Compounds; Molecular Docking; Minimum Inhibitory Concentration (MIC) Assay.



DOI: https://doi.org/10.36039/AA042019001.