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Transfer Learning-Based Approach for Early Detection of Alzheimer’s Disease .


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Alzheimer's disease is one of the world's main health concerns today. People with Alzheimer's disease who are diagnosed early have the best chance of receiving effective therapy. It's critical to catch the sickness as early as possible. Magnetic resonance imaging is one way to define Alzheimer's disease by finding structural abnormalities in the brain (MRI). We propose that machine learning, specifically trained convolutional neural networks (CNNs) with transfer learning capable of making predictions about similar brain imagery, can aid in early detection. CNN enables the extraction of MRI properties and classification as Alzheimer's disease or normal brain. We used the VGG19 architecture to categorize patients as having no signs of Alzheimer's disease or having signs of very mild, mild, or moderate Alzheimer's disease. Based on a transfer learning methodology, this method correctly classifies MRI images into four phases of Alzheimer's disease with an accuracy of 85 percent.

Keywords

--Alzheimers Disease, Transfer Learning, VGG19, MRI, CNN.
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  • Dementia statistics - Alzheimer’s diasease international. url: https://www.alz. co.uk/research/statistics.
  • Christina Patterson. World Alzheimer Report 2018 The state of the art of dementia research: New frontiers. Tech. rep. Alzheimer’s Disease International (ADI), London. 2018. DOI: 10.1111/j.0033-0124.1950.24{_}14.x url:https://www.alz.co.uk/research/WorldAlzheimerReport2018.pdf?2.
  • J. Mitchell and M. Shiri-Feshki, Rate of progression of mild cognitive impairment to dementia – a meta-analysis of 41 robust inception cohort studies, Acta Psychiatr. Scand., vol. 119, no. 4, pp. 252265, 2009
  • Csernansky, J.G., Wang, L., Swank, J., Miller, J.P., Gado, M., McKeel, D., et al., 2005. Preclinical detection of AD: hippocampal shape and volume predict dementia onset in the elderly. Neuroimage 25, 783–792.
  • Frisoni, Fox, Jack, Scheltens, Thompson. “The Clinical Use of Structural MRI in Alzheimer Disease” Nature Reviews Neurology, Feb 2010, https://www.nature.com/articles/nrneurol.2009.215
  • Plant, Teipel, Oswald, Bohm, Meindl, Mourao-Miranda, Bokde, Hampel, Ewers. “Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease” NeuroImage, Mar 2010, https://www.sciencedirect.com/science/article/pii/S1053811909012312?
  • via%3Dihub
  • S. Wang, H. Wang, Y. Shen, and X. Wang, "Automatic Recognition of Mild Cognitive Impairment and Alzheimer’s Disease Using Ensemble-based 3D Densely Connected Convolutional Networks," 2018 17th IEEE International Conference on Machine Learning and Applications (ICMLA), Orlando, FL, 2018, pp. 517-523, DOI: 10.1109/ICMLA.2018.00083.
  • Saad Albawi, Tareq Abed Mohammed, and Saad Al-Zawi.
  • “Understanding of a convolutional neural network”. In: 2017 International Conference on Engineering and Technology (ICET). IEEE.
  • , pp. 1–6.
  • Mr. Amir Ebrahimighahnavieh, Suhuai Luo, and Raymond Chiong.
  • “Deep learning to detect Alzheimer’s disease from neuroimaging: A systematic literature review”. In: Computer Methods and Programs in Biomedicine 187 (2020), p. 105242.
  • Taeho Jo, Kwangsik Nho, and Andrew J Saykin. “Deep learning in Alzheimer’s disease: diagnostic classification and prognostic prediction using neuroimaging data”. In: Frontiers in aging neuroscience 11 (2019), p. 220.
  • Patrik Kamencay et al. “A new method for face recognition using convolutional neural network”. In: (2017).
  • Keiron O’Shea and Ryan Nash. “An introduction to the convolutional neural networks”. In: arXiv preprint arXiv:1511.08458 (2015).
  • Phil Kim. “Convolutional neural network”. In: MATLAB deep learning.
  • Springer, 2017, pp. 121–147.
  • YA Bachtiar and T Adiono. “Convolutional Neural Network and Maxpooling Architecture on Zynq SoC FPGA”. In: 2019 International Symposium on Electronics and Smart Devices (ISESD). IEEE. 2019, pp.
  • –5.
  • Jawad Nagi et al. “Max-pooling convolutional neural networks for
  • vision-based hand gesture recognition”. In: 2011 IEEE International
  • Conference on Signal and Image Processing Applications (ICSIPA).
  • IEEE. 2011, pp. 342–347.
  • Arden Dertat. Applied Deep Learning - Part 4: Convolutional Neural
  • Networks. url:
  • https://towardsdatascience.com/applied-deep-learning-part-4-
  • convolutional-neural-networks-584bc134c1e2. (2018, June 19).
  • Lisa Torrey and Jude Shavlik. “Transfer learning”. In: Handbook of
  • research on machine learning applications and trends: algorithms,
  • methods, and techniques. IGI Global, 2010, pp. 242–264.
  • Yufeng Zheng, Clifford Yang, and Alex Merkulov. “Breast cancer screening using convolutional neural network and follow-up digital mammography”. In: Computational Imaging III. Vol. 10669.
  • International Society for Optics and Photonics. 2018, p. 1066905.
  • Kun He, Yan Wang, and John Hopcroft. “A powerful generative model using random weights for the deep image representation”. In: Advances in Neural Information Processing Systems 29 (2016), pp. 631–639.
  • Karen Simonyan and Andrew Zisserman. “Very deep convolutional networks for large-scale image recognition”. In: arXiv preprint arXiv: 1409.1556 (2014).
  • Manzak, G. Cetinel, and A. Manzak, “Automated Classification of Alzheimer’s Disease using Deep Neural Network (DNN) by Random Forest Feature Elimination”, vol. 19, pp. 1050-1053, August 2019.
  • F.J. Martinez-Murcia, A. Ortiz, J.M. Gorriz, J. Ramirez and D. CastilloBarnes, “Studying the Manifold Structure of Alzheimer’s Disease: A Deep Learning Approach Using Convolutional Autoencoders”, IEEE Journal of Biomedical and Health Informatics, pp. 1-10, 2019.
  • M. Menikdiwela, C. Nguyen and M. Shaw, “Deep learning on brain cortical thickness data for disease classification”, vol. 18, 2018.

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  • Transfer Learning-Based Approach for Early Detection of Alzheimer’s Disease .

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Authors

G. Nagarjuna Reddy
no, India
K. Vamsi Krishna
no, India
M. Rakesh Reddy
no, India
K. Ajay
no, India

Abstract


Alzheimer's disease is one of the world's main health concerns today. People with Alzheimer's disease who are diagnosed early have the best chance of receiving effective therapy. It's critical to catch the sickness as early as possible. Magnetic resonance imaging is one way to define Alzheimer's disease by finding structural abnormalities in the brain (MRI). We propose that machine learning, specifically trained convolutional neural networks (CNNs) with transfer learning capable of making predictions about similar brain imagery, can aid in early detection. CNN enables the extraction of MRI properties and classification as Alzheimer's disease or normal brain. We used the VGG19 architecture to categorize patients as having no signs of Alzheimer's disease or having signs of very mild, mild, or moderate Alzheimer's disease. Based on a transfer learning methodology, this method correctly classifies MRI images into four phases of Alzheimer's disease with an accuracy of 85 percent.

Keywords


--Alzheimers Disease, Transfer Learning, VGG19, MRI, CNN.

References