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Authors
Affiliations
1 V.P.M.M Engg College for Women, Krishanan
Koil, IN
2 R.V.S. Engg College, Dindigul, IN
3 V.P.M.M Engg College for Women, Krishanan Koil, IN
4 S.K.R Enggineering College, Chennai, IN
Source
Biometrics and Bioinformatics, Vol 6, No 2 (2014), Pagination:
Abstract
The harmful disease diagnosed at early stage is the important role of the medical field. The presence of Single nucleotide polymorphism causes DNA sequence difference, affects protein changing the structure and function, which causes the human genetic disease. The technique proposed for digital coding of amino acids in DNA sequences is by combining Codons and LDPC algorithm. The existing system extract the INTRON and EXON of genome by band pass FIR filter. The past work only graphical representation that is not helpful to the medical field. Hence our work towards the digital code of DNA sequence is realizable and reliable. Innovatively, this digital code based on Codons. The Codons is useful for DNA sequence compression during the compression no noise added that is the main advantage of proposed system. This proposed work make use of information theory to set up a model of digital coding, for amino acids.. It transforms the symbolic DNA sequences into digital genetic signals. The proposed LDPC based digital coding most commonly used for error detection and correction that offer huge advantages in terms of coding gain, throughput and power dissipation. The results also provide insight into the pattern of the variations that may have a direct role in the targeted disease and can be used to improve diagnostic reliability for complex human genetic disorders. The design model is tested for several databases of Homo sapiens DNA sequence which have been downloaded from National Center for Biotechnology Information (NCBI) homepage.
Keywords
LDPC, DNA Amino Codes, Codon.
