Insilico Function Prediction for Hypothetical Proteins in Vibrio Parahaemolyticus Chromosome II

The Vibrio parahaemolyticus is the potential food poisoning agent. The complete genome sequencing of Vibrio parahaemolyticus has been done which deciphered the presence of various gene for hypothetical proteins whose function is not yet understood. We analyzed complete genome of Vibrio parahaemolyticus for hypothetical proteins from which 458 were functionally classified into their respective protein families. Our attempt is to predict the functions of these hypothetical proteins by the application of computational methods and Bioinformatics. The probable function prediction of the hypothetical protein was done by using Bioinformatics web tools like CDD-BLAST, INTERPROSCAN, PFAM and COGs by searching sequence databases for the presence of orthologous enzymatic conserved domains in the hypothetical sequences. These study revealed presences of enzymatic functional domain in 458 uncharacterized proteins; their roles are yet to be discovered in Vibrio parahaemolyticus. These deciphered enzymatic data for hypothetical proteins can be used for the understanding of functional, structural, evolutionary and metabolic development of Vibrio parahaemolyticus and its life cycle along with their role in host evolution and pathogenicity.