A Review on Computational Methods for Protein Complex Detection

In cell biology, the protein complex plays a vital role. The initial step for understanding the protein function is the identification of protein complexes. Protein complex is a form of quaternary structure. It is similar to phosphorylation, and the   complex pattern frequently serve to trigger or reduce one or more of the connected proteins. The protein complexes are predicted from high through-put Protein-Protein Interaction (PPI) dataset. From PPI data, there are three sections of complexes such as Sparse complexes, embedded complexes and Small complexes remains challenging in nature. This paper discussed about the numerous computational methods to solve protein complex detection, tools, protein-protein interaction databases and various performance measures to assess the accuracy of the predicted result.