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Impact of Calorie Restriction on Epigenetic Factors and Metabolic Pathways During Senescence


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1 Department of Home Science (Foods and Nutrition), Banaras Hindu University, Varanasi (U.P.), India
     

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Ageing is an irreversible process associated with numerous physiological alterations across multiple organ systems. It is determined by genetic and epigenetic background in addition to environmental factors associated with social structure, culture and lifestyle. Recently different studies have shown that calorie restriction (CR) plays a noticeable role in the path of delaying senescence by modulating epigenetic factors and metabolic pathways. CR elicits co-ordinated adaptive stress responses at the cellular and whole organism level by modulating epigenetic mechanisms (e.g., DNA methylation, histone modification and miRNA modification ), signaling pathways that regulate cell growth and ageing (e.g., TOR, AMPK, p53 and FOXO ) and cell-to cell signaling molecules (e.g., adiponectin ). Despite of this fact, CR appears to be one of the common ways to increase lifespan in all species. Nutrient sensing pathways are also considered as contributing factors in ageing process because several nutrients can activate different pathways directly or indirectly. Therefore, this review paper focuses on how the epigenetic factors can be influenced by CR during senescence.

Keywords

Calorie Restriction, Cellular Metabolism, Ageing, Epigenetic Mechanism, Senescence.
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  • Anderson, R.M., Shanmuganayagam, D. and Weindruch, R. (2009). Calories restriction and ageing: studies in mice and monkeys. Toxicol. Pathol., 37(1):47-51.

  • Arita, Y., Kihara, S. and Ouchi, N. (1999). Paradoxical decrease of an adipose - specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commu., 257(1):79-83.

  • Bauer, J.H. and Helfand, S.L. (2009). Sir2 and longevity: The p53 connection. Cell Cycle, 8: 1818 - 1822.

  • Bestor, T.H. (2000). The DNA methyltransferases of mammals. Hum. Mol. Genet., 9(16): 2395-2402.

  • Bird, A. (2002). DNA methylation patterns and epigenetic memory. Genes. Dev., 16(1) : 6-21.

  • Budanov, A.V. and Karin, M. (2008). p53 target genes sestrin 1 and sestrin 2 connect genotoxic stress and mTOR signaling. Cell, 134 : 451- 460.

  • Choi, S.W. and Friso, S. (2010). Epigenetics: A New Bridge between Nutrition and Health, American Society for Nutrition. Adv. Nutr., 1 : 8-16.

  • Cunningham, J.T., Rodgers, J.T. and Arlow, D.H. (2007). mTOR controls mitochondrial oxidative function through a YY1-PGC-1 alpha transcriptional complex. Nature, 450 (7170) : 736-740.

  • Diez, J.J. and Iglesias, P. (2003). The role of the novel adipocyte derived hormone Adiponectin in human disease. Eur. J. Endocrinol., 148 (3) : 293-300.

  • Fenech, M., Sohemy, A. and Cahill, L. (2011). Nutrigenetics and Nutrigenomics : viewpoints on the current status and applications in Nutrition Research and Practice. J. Nutrigenet Nutrigenomics, 4 (2) : 69-89.

  • Feng, H., Shuda, M. and Chang, Y. (2008). Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science, 319 (5866): 1096-1100.

  • Feng, Z. (2010). p53 Regulation of the IGF-1 /AKT /mTOR Pathways and the Endosomal Compartment. Cold Spring Harb Perspect Biol., 2(2): a001057.

  • Feng, Z., Hu, W. and de, Stanchina E. (2007). The regulation of AMPK 1, TSC2 and PTEN expression by p53: Stress, cell and tissue specificity and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Canc. Res., 67 : 3043–3053.

  • Feng, Z., Zhang, H. and Levine, A.J. (2005). The co-ordinate regulation of the p53 and mTOR pathways in cells. Proc. Nat. Acad. Sci. U S A, 102: 8204 – 8209.

  • Fernandez-Real, J.M., Lopez-Bermejo, A. and Casamitjana, R. (2003). Novel interactions of adiponectin with the endocrine system and inflammatory parameters. J .Clin. Endocrinol. Metab., 88(6) : 2714-2718.

  • Fontana, L. and Klein, S. (2007). Aging, adiposity and calorie restriction. JAMA, 297 (9) : 986 - 994.

  • Goldberg, A.D., Allis, C.D. and Bernstein, E. (2007). Epigenetics: A landscape takes shape. Cell., 128 (4) : 635-638.

  • Gottlieb, T.M., Leal, J.F. and Seger, R. (2002). Cross talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis. Oncogene, 21(8) : 1299-1303.

  • Houde, V. P., Brule, S. and Festuccia, W.T. (2010). Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes. Metab. Res. Rev., 59 (6) : 1338-1348.

  • Houtkooper, R.H., Pirinen, E. and Auwerx, J. (2012). Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell. Biol., 13: 225 -238.

  • Isobe, M., Emanuel, B.S. and Givol, D. (1986). Localisation of gene for human p53 tumour antigen to band 17 p13. Nature, 320 (6057) : 84 - 85.

  • Jia, K., Chen, D. and Riddle, D.L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development, 131: 3897 - 3906.

  • Jung-Hynes, B. and Ahmad, N. (2009). Role of p53 in the antiproliferative effects of sirt1 inhibition in prostate cancer cells. Cell. Cycle, 8 (10) : 1478 - 1483.

  • Kern, S.E., Kinzler, K.W. and Burskin, A. (1991). Identification of p53 as a sequence DNA binding protein. Sci., 252 (5013) : 1708 - 1711.

  • King-Batoon, A., Leszczynska, J.M. and Catherine, B. (2008). Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ. Mol. Mutagen., 49 (1) : 36 - 45.

  • Lamming, D.W., Ye, L. and Katajisto, P. (2012). Rapamycin - induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science, 335 (6076) : 1638 - 1643.

  • Le, Bourg E. (2009). Hormesis, aging and longevity. Biochim Biophys Acta., 1790 : 1030 - 1039.

  • Levine, A.J., Feng, Z. and Mak, T.W. (2006a). Coordination and communication between the p53 and IGF-1- AKTTOR signal transduction pathways. Genes. Dev., 20 (3) : 267-275.

  • Levine, A.J., Hu, W. and Feng, Z. (2006b). The P53 pathway: What questions remain to be explored ? Cell. Death Differ., 13 (6) : 1027-1036.

  • Li, Y. and Tollefsbol, T.O. (2010). Dietary effect on epigenetics during the aging process. Epigenet., Aging, 407-416.

  • Link, A., Balaguer, F. and Goel, A. (2010). Cancer chemoprevention by dietary polyphenols : promising role for epigenetics. Biochem Pharm., 80 (12) : 17711792.

  • Majid, S., Dar, A. A. and Ahmad, A.E. (2009). BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis, 30 (4) : 662 -670.

  • Mathers, J.C. (2008). Session 2: Personalised nutrition. Epigenomics :a basis for understanding individual differences? Proc. Nutr. Soc., 67 (4) : 390-394.

  • Mathers, J.C., Strathdee, G. and Relton, C.L. (2010). Induction of epigenetic alterations by dietary and other environmental factors. Adv. Genet., 71 (4) : 3 - 39.

  • Matlashewski, G., Lamb, P. and Pim, D. (1984). Isolation and characterization of a human p53 cDNA clone : expression of the human p53 gene. EMBO J., 3 (13) : 3257-3262.

  • Matthew, E.M., Lori, S.H. and Aristotelis, Astrinidis (2009). The p53 target PIK2 interacts with TSC proteins impacting mTOR signalling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle, 8 (24) : 4168 - 4175.

  • McBride, W., Merry, D. and Givol, D. (1986). The gene for human p53 cellular antigen is located on chromosome 17shortarm (17p13 ). Proc. Nat. Acad. Sci. USA, 83 (1) : 130 - 134.

  • McKay, J.A. and Mathers, J.C. (2011). Diet induced epigenetic changes and their implications for health. Acta. Physiol., 202 (2) : 103 - 118.

  • Muddulurun, G., George-William, J.N. and Muppala, S. (2011). Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer. Biosci. Rep., 31(3) : 185 - 197.

  • North, B.J., Marshell, B.L. and Borra, M.T. (2003). The human Sir2 ortholog, SIRT2, is an NAD+ dependent tubulin deacetylase. Mol. Cell., 11 (2) : 437-444.

  • Oldham, S. and Hafen, E. (2003). Insulin/IGF and target of rapamycin signaling: a TOR de force in growthcontrol. Trends Cell. Biol., 13 : 79-85.

  • Radak, Z., Koltai, E. and Taylor, A.W. (2013). Redox regulating sirtuins in aging, caloric restriction, and exercise. Free Radic. Biol. Med., 58 : 87-97.

  • Ramanathan, A. and Schreiber, S.L. (2009). Direct control of mitochondrial function by mTOR. Proc. Nat. Acad. Sci. USA, 106 (52) : 22229-22232.

  • Read, A.P. and Stranchan, T. (1999). Human molecular genetics 2. Wiley, ISBN 0-471-33061-2. Chapter 18: Cancer Genet., NEWYORK, U.S.A.

  • Reik, W. (2007). Stability and flexibility of epigenetic gene regulation in mammalian development. Nature, 447 (7143) : 425-432.

  • Renaldi, O., Pramono, B. and Sinorita, H. (2009). Hypoadiponectinemia : a risk factor for metabolic syndrome. Acta. Med. Indones, 41 (1) : 20-24.

  • Ribaric, S. (2012). Diet and aging. Oxid Med Cell Longev 2012, Article ID 741468, 20 pages. doi:10.1155/2012/ 741468.

  • Ristow, M. and Zarse, K. (2010). How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormosis. Exp. Geronot., 45(6) : 410 - 418.

  • Saha, A.K., Xu, X. and Balon, T.W. (2011). Insulin resistance due to nutrient excess: Is it a consequence of AMPK down regulation? Cell Cycle, 10 : 3447-3451.

  • Salminen, A. and Kaarniranta, K. (2012). AMP – activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev., 11: 230-241.

  • Schieke, S.M., Phillips, D. and McCoy, J.P. (2006). The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J. Biol. Chem., 281 (37) : 2764327652.

  • Shankar, S., Kumar, D. and Srivastava, R.K. (2013). Epigenetic modifications by dietary phytochemicals: Implications for personalized nutrition. Pharmacol. Ther., 138 (1) : 1-17.

  • Stambolic, V., Mac, Pherson D. and Sas, D. (2001). Regulation of PTEN transcription by p53. Mol. Cell., 8: 317-325.

  • Stefan, N., Vozarova, B. and Funahashi, T. (2002). Plasma adiponectin concentration is associated with skeletal muscle insulin receptor in whole-body insulin sensitivity in humans. Diabetes, 51 (6) : 1884-1888.

  • Tili, E., Michaille, J.J. and Alder, H. (2010). Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGF signaling pathway in SW480 cells. Biochem. Pharmacol., 80 (12) : 2057-2065.

  • Tsang, W.P. and Kwok, T.T. (2010). Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J. Nutr. Biochem., 21(2) : 140–146.

  • Tucci, P. (2012). Caloric restriction: is mammalian life extension linked to p53 ? Aging, 4 (8) : 525 - 534.

  • Ukkola, O. and Santaniemi, M. (2002). Adiponectin: a link between excess adiposity and associated comorbidities? J. Mol. Med., 80 (11) : 696-702

  • Vogelstein, B., Lane, D. and Levine, A.J. (2000). Surfing the p53 network. Nature, 408 (6810) : 307-310.

  • Vousden, K. H. and Prives, C. (2009). Blinded by the light: The growing complexity of p53. Cell., 137 : 413 - 431.

  • Waterland, R.A. and Jirtle, R.L. (2004). Early Nutrition, epigenetic changes at transposons and imprinted genes and enhanced susceptibility to adult chronic diseases. Nutrition, 20 : 63-68.

  • Weyer,C., Funahashi, T. and Tanaka, S. (2001). Hypoadiponectinemia in obesity and type 2 diabetes: a close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab., 86 (5) : 1930–1935.

  • Ye, L., Varamini, B. and Lamming, D.W. (2012). Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2. Front Genet., 3 (177) : 1-10.

  • Yen, W.L. and Klionsky, D.J. (2008). How to live long and prosper : Autophagy, mitochondria and aging. Pysiology, 23 : 248- 262.

  • Zhu, M., Lee, G.D. and Ding, L. (2007). Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction. Exp. Geront.,42 (8) : 733744.

  • http://dx.doi.org/10.1016/j.pharmthera.2012.11.002.

  • Retrived February 24 (2013). from http:// www.abcam.com / index.html? pageconfig= resource&rid=15297.


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  • Impact of Calorie Restriction on Epigenetic Factors and Metabolic Pathways During Senescence

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Authors

Upasana
Department of Home Science (Foods and Nutrition), Banaras Hindu University, Varanasi (U.P.), India
Shaista Parveen
Department of Home Science (Foods and Nutrition), Banaras Hindu University, Varanasi (U.P.), India
Archana Chakravarty
Department of Home Science (Foods and Nutrition), Banaras Hindu University, Varanasi (U.P.), India

Abstract


Ageing is an irreversible process associated with numerous physiological alterations across multiple organ systems. It is determined by genetic and epigenetic background in addition to environmental factors associated with social structure, culture and lifestyle. Recently different studies have shown that calorie restriction (CR) plays a noticeable role in the path of delaying senescence by modulating epigenetic factors and metabolic pathways. CR elicits co-ordinated adaptive stress responses at the cellular and whole organism level by modulating epigenetic mechanisms (e.g., DNA methylation, histone modification and miRNA modification ), signaling pathways that regulate cell growth and ageing (e.g., TOR, AMPK, p53 and FOXO ) and cell-to cell signaling molecules (e.g., adiponectin ). Despite of this fact, CR appears to be one of the common ways to increase lifespan in all species. Nutrient sensing pathways are also considered as contributing factors in ageing process because several nutrients can activate different pathways directly or indirectly. Therefore, this review paper focuses on how the epigenetic factors can be influenced by CR during senescence.

Keywords


Calorie Restriction, Cellular Metabolism, Ageing, Epigenetic Mechanism, Senescence.

References