Journal of Horticultural Sciences

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A Guide to in silico Identification of miRNAs and their Targets


Affiliations
1 Division of Biotechnology, ICAR-Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru – 560 089, India
 

MicroRNAs (miRNA) are non-coding RNA molecules that play a critical role in gene regulation including translational repression in animals and mRNA cleavage in plants. MicroRNAs control various cellular, metabolic and physiological processes in living organisms. In this paper, we provide an overview on the significance of miRNA, nomenclature, their biogenesis and the pipelines for prediction of miRNA and their targets. These tools are important for identification of conserved miRNAs in crops where miRNAs have not been previously discovered. The newlyidentified miRNAs and their targets play an important role in understanding regulation of growth, development and gene silencing in various life forms.

Keywords

miRNA, Bioinformatics, miRNA Targets, Structure, Software Tools.
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  • A Guide to in silico Identification of miRNAs and their Targets

Abstract Views: 319  |  PDF Views: 120

Authors

V. Radhika
Division of Biotechnology, ICAR-Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru – 560 089, India
Kanupriya
Division of Biotechnology, ICAR-Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru – 560 089, India
R. Rashmi
Division of Biotechnology, ICAR-Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru – 560 089, India
C. Aswath
Division of Biotechnology, ICAR-Indian Institute of Horticultural Research, Hessaraghatta Lake Post, Bengaluru – 560 089, India

Abstract


MicroRNAs (miRNA) are non-coding RNA molecules that play a critical role in gene regulation including translational repression in animals and mRNA cleavage in plants. MicroRNAs control various cellular, metabolic and physiological processes in living organisms. In this paper, we provide an overview on the significance of miRNA, nomenclature, their biogenesis and the pipelines for prediction of miRNA and their targets. These tools are important for identification of conserved miRNAs in crops where miRNAs have not been previously discovered. The newlyidentified miRNAs and their targets play an important role in understanding regulation of growth, development and gene silencing in various life forms.

Keywords


miRNA, Bioinformatics, miRNA Targets, Structure, Software Tools.

References