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A Novel Study of Lichen Planopilaris among Different Iranian Ethnicities Based on Computer-Aided Programs


Affiliations
1 Tehran University of Medical Sciences (TUMS), Tehran, Iran, Islamic Republic of
2 Applied AI and Data Science Group, Mærsk McKinney Møller Institute (MMMI), University of Southern Denmark (SDU), Odense, Denmark, Denmark
 

Introduction: Demographic studies of a disease can reveal the characteristics of that disease among a specific population and will help the physicians to achieve a more accurate perception about it.The demographic of Lichen PlanoPilaris (LPP) among the Iranian population is unknown. The aim of this study is to describe the clinical, demographic, and histopathologic findings of lichen planopilaris in the Iranian population.

Materials and Methods: In this cross-sectional study, all the patients with Lichen planopilaris were referred to the dermatology clinic of Imam Khomeini hospital from 2013 to 2015. Lichen planopilaris can be diagnosed by collecting histological evidence, dermatological examination, and clinical diagnosis. Their demographic characteristics, drug histories, onset of disease, and family histories were obtained by written questionnaire. Additionally, this study employed SPSS v.20 as the statistical analysis software.

Results: One hundred patients were enrolled in this study. With an average age of 47.11 years, 78% of the patients were female, and 50 of these were housewives. The patients included were often from Tehran with Fars ethnicity. Among these patients, 7 had alopecia areata skin disease, and 10 of them suffered from thyroid disease. Most of the histopathology samples collected from these biopsies revealed degeneration of the basal layer of the follicular structure, perifollicular fibrosis, inflammatory cells, and atrophy of the pilosebaceous structures.

Conclusion: Both the age spectrum and the disease distribution of LPP among the Iranian population were very diverse when compared to previous studies. Moreover, this study helps the physicians to have a brighter vision about the main reason and cause of LPP spread among diverse Iranian Ethnicities.


Keywords

Clinical Features, Epidemiologic, Demographics, Histology, Lichen PlanoPilaris (LPP), Statistical Package for the Social Sciences (SPSS).
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  • Ochoa BE, King LE Jr, Price VH. Lichen planopilaris: Annual incidence in four hair referral centers in the United States. J Am Acad Dermatol 2008; 58:352.

  • Vañó-Galván S, Molina-Ruiz AM, Serrano-Falcón C, et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol 2014; 70:670.

  • Tan KT, Messenger AG. Frontal fibrosing alopecia: clinical presentations and prognosis. Br J Dermatol 2009; 160:75.

  • Atanaskova Mesinkovska N, Brankov N, Piliang M, et al. Association of lichen planopilaris with thyroid disease: a retrospective case-control study. J Am Acad Dermatol 2014; 70:889.

  • Mobini N, Tam S, Kamino H. Possible role of the bulge region in the pathogenesis of inflammatory scarring alopecia: lichen planopilaris as the prototype. J Cutan Pathol 2005; 32:675.

  • Assouly P, Reygagne P. Lichen planopilaris: update on diagnosis and treatment. SeminCutan Med Surg 2009; 28:3.

  • Tosti A, Piraccini BM, Iorizzo M, Misciali C. Frontal fibrosing alopecia in postmenopausal women. J Am Acad Dermatol 2005; 52:55.

  • Matta M, Kibbi AG, Khattar J, et al. Lichen planopilaris: a clinicopathologic study. J Am AcadDermatol 1990; 22:594.

  • Giménez-García R, Lázaro-Cantalejo TE, Sánchez-Ramón S, Velasco Fernandez C. Linear lichen planopilaris of the face. J Eur Acad Dermatol Venereol 2005; 19:770.

  • Duque-Estrada B, Tamler C, Sodré CT, et al. Dermoscopy patterns of cicatricial alopecia resulting from discoid lupus erythematosus and lichen planopilaris. An Bras Dermatol 2010; 85:179.

  • Ioffreda MD. Inflammatory diseases of hair follicles, sweat glands, and cartilage. In: Lever's Histopathology of the Skin, 10th ed, Elder DE (Ed), Lippincott Williams & Wilkins, Philadelphia 2009. p.459.

  • Rácz E, Gho C, Moorman PW, et al. Treatment of frontal fibrosing alopecia and lichen planopilaris: a systematic review. J Eur Acad Dermatol Venereol 2013; 27:1461.

  • Chiang C, Sah D, Cho BK, et al. Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system. J Am Acad Dermatol 2010; 62:387.

  • Spencer LA, Hawryluk EB, English JC 3rd. Lichen planopilaris: retrospective study and stepwise therapeutic approach. Arch Dermatol 2009; 145:333.

  • Baibergenova A, Walsh S. Use of pioglitazone in patients with lichen planopilaris. J Cutan Med Surg 2012; 16:97.

  • Mehregan DA, Van Hale HM, Muller SA. Lichen planopilaris: clinical and pathologic study of fortyfive patients. J Am AcadDermatol 1992; 27:935.

  • Tan E, Martinka M, Ball N, Shapiro J. Primary cicatricialalopecias: clinicopathology of 112 cases. J Am Acad Dermatol 2004; 50:25.


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  • A Novel Study of Lichen Planopilaris among Different Iranian Ethnicities Based on Computer-Aided Programs

Abstract Views: 289  |  PDF Views: 131

Authors

Maryamsadat Nejadghaderi
Tehran University of Medical Sciences (TUMS), Tehran, Iran, Islamic Republic of
Ashkan Tashk
Applied AI and Data Science Group, Mærsk McKinney Møller Institute (MMMI), University of Southern Denmark (SDU), Odense, Denmark, Denmark
Parvin Mansouri
Tehran University of Medical Sciences (TUMS), Tehran, Iran, Islamic Republic of
Zahra Safaei Naraghi
Tehran University of Medical Sciences (TUMS), Tehran, Iran, Islamic Republic of

Abstract


Introduction: Demographic studies of a disease can reveal the characteristics of that disease among a specific population and will help the physicians to achieve a more accurate perception about it.The demographic of Lichen PlanoPilaris (LPP) among the Iranian population is unknown. The aim of this study is to describe the clinical, demographic, and histopathologic findings of lichen planopilaris in the Iranian population.

Materials and Methods: In this cross-sectional study, all the patients with Lichen planopilaris were referred to the dermatology clinic of Imam Khomeini hospital from 2013 to 2015. Lichen planopilaris can be diagnosed by collecting histological evidence, dermatological examination, and clinical diagnosis. Their demographic characteristics, drug histories, onset of disease, and family histories were obtained by written questionnaire. Additionally, this study employed SPSS v.20 as the statistical analysis software.

Results: One hundred patients were enrolled in this study. With an average age of 47.11 years, 78% of the patients were female, and 50 of these were housewives. The patients included were often from Tehran with Fars ethnicity. Among these patients, 7 had alopecia areata skin disease, and 10 of them suffered from thyroid disease. Most of the histopathology samples collected from these biopsies revealed degeneration of the basal layer of the follicular structure, perifollicular fibrosis, inflammatory cells, and atrophy of the pilosebaceous structures.

Conclusion: Both the age spectrum and the disease distribution of LPP among the Iranian population were very diverse when compared to previous studies. Moreover, this study helps the physicians to have a brighter vision about the main reason and cause of LPP spread among diverse Iranian Ethnicities.


Keywords


Clinical Features, Epidemiologic, Demographics, Histology, Lichen PlanoPilaris (LPP), Statistical Package for the Social Sciences (SPSS).

References