International Journal of Innovative Research and Development

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Microwave-Assisted, Palladium Catalyzed Synthesis of Novel 4,6-Diamino Pyrimidine Derivatives


Affiliations
1 Department of Chemistry, Srinivas School of Engineering, Mukka, Mangalore, Karnataka, India
2 P.G. Department of Chemistry, Kuvempu University, Shankaraghatta, Shimoga, India
 

Great challenging second nucleophilic substitution of pyrimidine reaction was achieved by palladium catalyzed coupling reaction at higher temperature under microwave irradiation in closed system using 1,4-dioxane as solvent with high yield. Further, structures of these newly synthesized compounds were confirmed by spectral and elemental analysis.


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  • Microwave-Assisted, Palladium Catalyzed Synthesis of Novel 4,6-Diamino Pyrimidine Derivatives

Abstract Views: 171  |  PDF Views: 2

Authors

Poornima Shetty
Department of Chemistry, Srinivas School of Engineering, Mukka, Mangalore, Karnataka, India
B. M. Praveen
Department of Chemistry, Srinivas School of Engineering, Mukka, Mangalore, Karnataka, India
Srinivas Cheruku
Department of Chemistry, Srinivas School of Engineering, Mukka, Mangalore, Karnataka, India
T. V. Venkatesha
P.G. Department of Chemistry, Kuvempu University, Shankaraghatta, Shimoga, India
Vathsala Mahesh
P.G. Department of Chemistry, Kuvempu University, Shankaraghatta, Shimoga, India

Abstract


Great challenging second nucleophilic substitution of pyrimidine reaction was achieved by palladium catalyzed coupling reaction at higher temperature under microwave irradiation in closed system using 1,4-dioxane as solvent with high yield. Further, structures of these newly synthesized compounds were confirmed by spectral and elemental analysis.