Design, Synthesis and Pharmacological Evaluation of Novel Bis Acid Amides as Antibacterial and Anti-Inflammatory Agents

Opening of the five-member ring of dihydrofuran-2,5-dione with amines was used to synthesize a series of amides of4-oxo-4-(substituted) butanoic acid.4-oxo-4-(substituted) butanoic acidamine coupling using 1,1'-carbonyldiimidazole (CDI) was designed to synthesize newbis-acid amide derivatives and pharmacological activities of the compounds were evaluated. Good functional group transformations were observed upon conventional synthesis. Infrared spectroscopy (IR), ¹H and ¹³C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analysis were used to establish the structures of the newly synthesized compounds. All the compounds were tested for in-vitro antibacterial and anti-inflammatory activity, some of the compounds were proven to be potent antibacterial and anti-inflammatory agents.