International Journal of Innovative Research and Development

Abstract

An efficient protocol for the synthesis of N-protected diazomethylketone was developed using (1-cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholinomethylene) methanaminium hexa-fluorophosphate (COMU) and N-nitrosourea (NNU) is developed.  Conversion of carboxylic acids to diazomethylketones in an excellent yield was obtained under milder reaction conditions, through a simple workup. Further, the synthesized compounds were used for the preparation of bromomethylketones using 45% aqueous HBr and selenazoles. Prepared bromomethylketones were subjected for their antibacterial activity against Escherichia coli and Staphylococcus aureus strains and antioxidant studies. Antibacterial activity reveals that the compound Fmoc-Phe-CO-CH₂-Br exhibited the zone of inhibition with respect to Streptomycin sulphate standard. For antioxidant assay, % RSC of Fmoc-Ala-CO-CH-N₂, Fmoc-Phe-CO-CH₂-Br and Fmoc-Phe-CO-CH-N₂ exhibited free radical inhibition or scavenger activity with 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The synthesized compounds were characterized by HRMS, ¹H NMR, and ¹³C NMR studies.

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Abstract

The evolution of traditional library collections to digital or virtual collections has given new dimension. The Internet, Web environment and associated sophisticated tools have given a new dynamic role to play and serve the new information based society in better ways than previously. Because of the powerful features of Web i.e. distributed, heterogeneous, collaborative, multimedia, multi-protocol, hypermedia-oriented architecture, World Wide Web has revolutionized the way people access information, and has opened up new possibilities in areas such as digital libraries, virtual libraries, scientific information retrieval and dissemination. For above list there is a new addition called “cloud computing”, it is a new technology which uses Internet and central remote servers to keep up data and applications. The article gives an overview of limitless scope of cloud computing using internet and web, the role of cloud computing in sharing of information resources through internet and web environment especially as intermediary, facilitator, knowledge manager and shifter of information resources is also described.

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