Molecular Modeling of Ribosomal Protein L4 in HUNGARY 19A-6 Strain of Streptococcus pneumoniae and Analysis of Lead Molecular Interaction

Streptococcus pneumoniae is the major bacterial pathogen causing severe respiratory infections such as pneumonia, meningitis and septicaemia. HUNGARY19A-6 strain of Streptococcus pneumoniae is extremely virulent in pneumococcal pathogenesis which contains rpLD gene which synthesis Ribosomal protein L4. In this article we performed the insilico modeling studies of the virulent protein which is synthesized by the rpLD gene and validated the nature of the receptor based on their atomic interactions for future drug target for HUNGARY19A-6 strain of Streptococcus pneumoniae. We have also analyzed drug targets for the above mentioned protein by using the virtual structure based ligand screening approach. Protein-ligand complexes have been analyzed by docking studies using Discovery Studio and interactions have also been visualized along with the validation of pharmacokinetic descriptors.