Open Access
Subscription Access
Open Access
Subscription Access
Sensitivity and Specificity of High-Resolution Computed Tomography in Diagnosis of COVID-19 in Emergency Department: A Single Centre Study
Subscribe/Renew Journal
Aim: To evaluate the performance of chest computed tomography (CT) scan in the preliminary diagnosis of suspected coronavirus disease 2019 (COVID-19).
Material and methods: Suspected 1149 COVID-19 patients who underwent both chest CT and RT-PCR tests were included. Considering RT-PCR as a reference standard, the performance of chest CT in diagnosing COVID-19 was evaluated. Obtained data was statistically analysed for sensitivity, specificity and accuracy for the diagnosis of COVID-19 cases.
Results: Out of 1149 patients RTPCR was positive in 188 (16.36%) of patients and CT findings were positive in 368 (32.03%) of patients. The majority (21.15%) of the patients’ CT scan revealed sub-pleural ground-glass opacities (GGO), consolidation was seen in 76 (6.61%), pleural effusion in 73 (6.35%) and interstitial oedema in 41 (6.35%) respectively. Considering RT-PCR results as the reference standard, the chest CT revealed a sensitivity of 73.40%, specificity of 76.07% and accuracy of 75.63% in identifying COVID 19.
Conclusion: Chest CT revealed diagnostic accuracy (75.63%) in diagnosing COVID-19 and it could be considered as a basic modality for detecting COVID-19 cases early. This can be valuable to initiate early triage and infection control practices and appropriate isolation strategies in Emergency Department.
Keywords
- Bloom DE, Cadarette D. Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response. Front Immunol. 2019 Mar 28;10:549.
- Binder S, Levitt AM, Sacks JJ, Hughes JM. Emerging infectious diseases: public health issues for the 21st century. Science. 1999 May 21;284(5418):1311-3.
- Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci. 2020 Mar 15;16(10):1678-1685.
- Cobo F. Application of molecular diagnostic techniques for viral testing. Open Virol J. 2012;6:104-14.
- Kubina R, Dziedzic A. Molecular and Serological Tests for COVID-19 a Comparative Review of SARS-CoV-2 Coronavirus Laboratory and Point-of-Care Diagnostics. Diagnostics (Basel). 2020 Jun 26;10(6):434.
- Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, et al. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). J MicrobiolBiotechnol. 2020 Mar 28;30(3):313-324.
- Chawla S, Saxena SK. Preparing for the Perpetual Challenges of Pandemics of Coronavirus Infections with Special Focus on SARS-CoV-2. Coronavirus Disease 2019 (COVID-19). 2020 Apr 30:165–86.
- Stegeman I, Ochodo EA, Guleid F, Holtman GA, Yang B, Davenport C, et al. Cochrane COVID-19 Diagnostic Test Accuracy Group. Routine laboratory testing to determine if a patient has COVID-19. Cochrane Database Syst Rev. 2020 Nov 19;11:CD013787.
- Kim H, Hong H, Yoon SH. Diagnostic Performance of CT and Reverse Transcriptase Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis. Radiology. 2020 Sep;296(3):E145-E155.
- Duarte ML, Santos LRD, Contenças ACS, Iared W, Peccin MS, Atallah ÁN. Reverse-transcriptase polymerase chain reaction versus chest computed tomography for detecting early symptoms of COVID-19. A diagnostic accuracy systematic review and meta-analysis. Sao Paulo Med J. 2020 SepOct;138(5):422-432.
- Young D, Tatarian L, Mujtaba G, Chow P, Ibrahim S, Joshi G, et al. (2020) Chest CT versus RT-PCR for Diagnostic Accuracy of COVID-19 Detection: A Meta-Analysis. J Vasc Med Surg 8:3.
- Korevaar DA, Kootte RS, Smits LP,van den Aardweg JG, Bonta PI, Schinkel J, et al. Added value of chest CT in suspected COVID-19: an analysis of 239 patients. Eur Respir J 2020; in press
- Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020 Aug;296(2):E32-E40.
- Yang Y, Yang M, Shen C, Wang F, Yuan J, Li J, et al. Evaluating the accuracy of different respiratory specimens in the laboratory diagnosis and monitoring the viral shedding of 2019-nCoV infections. medRxiv; 2020. DOI: 10.1101/2020.02.11.20021493.
- Guan WJ, Ni ZY, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med.2020;382:1708-1720.
- Karam M, Althuwaikh S, Alazemi M, Abul A, Hayre A, Alsaif A, et al. Chest CT versus RT-PCR for the Detection of COVID-19: Systematic Review and Meta-analysis of Comparative Studies. medRxiv 2020.06.22.20136846.
Abstract Views: 244
PDF Views: 0