Thrombolysis in a Case of Cardiac Arrest due to Massive Pulmonary Embolism with Ongoing CardioPulmonary Resuscitation: a Case Report
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Pulmonary embolism (PE) is a life-threatening condition which often gets missed due to non-specific initial presentation in the Emergency Department (ED). We report a case of a young male who presented to the ED with sudden onset breathlessness and diaphoresis. Appropriate resuscitation was initiated. Soon after patient started gasping and had a cardiac arrest with first monitored rhythm being pulseless electrical activity (PEA). Cardio-pulmonary resuscitation (CPR) was initiated and continued as per ACLS protocol. Portable Echocardiograph revealed severe pulmonary hypertension with right ventricular dysfunction. Provisional diagnosis of PE was made and patient was managed with immediate thrombolysis with ongoing CPR. Brief episodes of cardiac arrest occurred which were successfully revived following which he remained hemodynamically stable. Diagnosis was confirmed by Colour Doppler of bilateral lower limbs and pulmonary angiogram. Patient was weaned off ventilator within 24 hours and discharged home after a week with full neurological recovery. Timely diagnosis and management were key in this patient’s survival.
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- KürkciyanI, MeronG, SterzF,Janata K, Domanovits H, Holzer M, Berzlanovich A, Bankl HC, Laggner AN.Pulmonary embolism as a cause of cardiac arrest:presentation and outcome.JAMA Internal Medicine, 2000;160(10):1529–1535.
- Hauch O, Jørgensen LN, Khattar SC, Teglbjaerg CS, Wåhlin AB, Rathenborg P, Wille-Jørgensen P. Fatal pulmonary embolism associated with surgery. An autopsy study. Acta Chir Scand. 1990 Nov-Dec;156(11-12):747-9.
- Truhlar A, Deakin CD, Soar J, Khalifa GE, Alfonzo A, Bierens JJ, Brattebø G, Brugger H, Dunning J, Hunyadi-Anticevic S, Koster RW, Lockey DJ, Lott C, Paal P, Perkins GD, Sandroni C, Thies KC, Zideman DA, Nolan JP. Cardiac arrest in special circumstances section Collaborators. European Resuscitation Council Guidelines for Resuscitation 2015: Section 4: Cardiac arrest in special circumstances. Resuscitation 2015;95:148-201.
- MacCarthy P, Worrall A, McCarthy G, Davies J. The use of transthoracicechocardiography to guide thrombolytic therapy during cardiac arrest due to massivepulmonary embolism.Emergency Medicine Journal, 2002; 19(2):178-179.
- Ruiz-Bailen M, Aguayo-de-Hoyos E, Serrano-Corcoles MC,et al. Thrombolysis with recombinant tissue plasminogen activator during cardiopulmonary resuscitation in fulminant pulmonary embolism. A case series. Resuscitation 2001;51:97–101.
- Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M, Konstantinides S, Prandoni P, Muriel A, Yusen RD; PROTECT Investigators. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. ThrombHaemost 2016;115:827-834
- Goldhaber SZ, Come PC, Lee RT, Braunwald E, Parker JA,Haire WD, Feldstein ML, Miller M, Toltzis R, Smith JL,Taveira da Silva AM, Mogtader A, McDonough TJ. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet 1993;341:507-511.
- Bottiger BW, Bohrer H, Bach A, Motsch J, Martin E. Bolus injection of thrombolytic agents during cardiopulmonary resuscitation for massive pulmonary embolism. Resuscitation 1994;28:45–54.
- Böttiger BW, Arntz HR, Chamberlain DA, Bluhmki E, Belmans A, Danays T, Carli PA, Adgey JA,Bode C, Wenzel V; TROICA Trial Investigators; European Resuscitation Council Study Group.Thrombolysis during resuscitation for out-ofhospital cardiac arrest. N Engl J Med.2008;359:2651– 2662. doi: 10.1056/NEJMoa070570.
- Li X, Fu QL, Jing XL, Li YJ, Zhan H, Ma ZF, Liao XX. A meta-analysis of cardiopulmonary resuscitation with and without the administration of thrombolytic agents. Resuscitation.2006 Jul;70(1):31-6. doi: 10.1016/j.resuscitation.2005.11.016. Epub 2006 Jun 9. PMID: 16762481.
- Janata K, Holzer M, Kurkciyan I, Losert H, Riedmüller E,Pikula B, Laggner AN, Laczika K. Major bleeding complications in car-diopulmonaryresuscitation: the place of thrombolytic therapy in cardiac arrest due to massive pulmonaryembolism. Resuscitation 2003;57:49–55.
- Er F, Nia AM, Gassanov N, Caglayan E, Erdmann E, Hoppe UC. Impact of rescue-thrombolysis during cardiopulmonary resuscitation in patients with pulmonary embolism. PLoS One. 2009;4:e8323. doi: 10.1371/journal.pone.0008323.
- Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, Sawyer KN, Donnino MW. Part 10: special circumstances of resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015;132 Suppl 2:S501–S518. doi: 10.1161/CIR.0000000000000264.
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