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Krishna, K.
- Olanzapine Induced Diabetic Ketoacidosis: Inadvertent Suffering
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Authors
Affiliations
1 Department of Medicine, BharatiVidyapeeth Medical College and Bharati Hospital, Pune-411043 and Krishna K, Bungalow No. 23, Sopan Baug Coop. Housing Society, Pune 411001, Maharashtra, IN
2 Department of Medicine, Bharati Vidyapeeth Medical College, IN
1 Department of Medicine, BharatiVidyapeeth Medical College and Bharati Hospital, Pune-411043 and Krishna K, Bungalow No. 23, Sopan Baug Coop. Housing Society, Pune 411001, Maharashtra, IN
2 Department of Medicine, Bharati Vidyapeeth Medical College, IN
Source
The Indian Practitioner, Vol 67, No 10 (2014), Pagination: 639-640Abstract
A 24 year old male was admitted to the hospital, suffering from compensated ketoacidosis and high blood sugar levels. On detailed history it was revealed that he was on olanzapine for more than 6 months as a part of treatment for bipolar disorder. Blood sugars were initially managed by intravenous and later by subcutaneous actrapid insulin. A proposed diagnosis of type I Diabetes mellitus vs Olanzapine induced DKA was put forward. Patient's requirement of insulin came down after olanzapine was discontinued.Keywords
No Keywords given
- TROXIPIDE: A Novel Cytoprotective Agent in Acid Peptic Disorders
Abstract Views :189 |
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Authors
Affiliations
1 Bungalow no. 23. Sopan Baug Coop Hsg Society, Pune 411001, Maharashtra, IN
1 Bungalow no. 23. Sopan Baug Coop Hsg Society, Pune 411001, Maharashtra, IN
Source
The Indian Practitioner, Vol 67, No 6 (2014), Pagination: 373-375Abstract
Gastritis and gastric ulcers are highly prevalent diseases among the Asian population. Patients approach for treatment only when disease related symptoms become severe.1 Treatment of gastric ulcers varies depending on the aetiology and clinical presentation. Acid suppression is the general pharmacologic principle of medical management of acute bleeding from a peptic ulcer, using histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) and cytoprotective agents (antacids, sucralfate).2 All these agents are available in intravenous or oral preparations and their efficacy is well established. Gastric defensive factors play a much significant role in gastric disorders so there was a need for drugs to normalise the gastric mucosal constitution and other defensive mediators including cytoprotective prostaglandins and gastric microcirculation.- A New Ray of Hope for Uncomplicated Falciparum Malaria in India - A Critical Review
Abstract Views :191 |
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Authors
Affiliations
1 Department of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Bungalow no 23. Sopan Baug Coop Hsg Society, Pune 411001, Maharashtra, IN
2 Pharm D Programme, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune, Maharashtra 411043, IN
3 PharmD Programme, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune, Maharashtra 411043, IN
1 Department of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Bungalow no 23. Sopan Baug Coop Hsg Society, Pune 411001, Maharashtra, IN
2 Pharm D Programme, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune, Maharashtra 411043, IN
3 PharmD Programme, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Pune, Maharashtra 411043, IN
Source
The Indian Practitioner, Vol 67, No 8 (2014), Pagination: 490-494Abstract
No Abstract.- Clinical Profile of Seronegative Spondyloarthropathies with Special Reference to Cardiac Involvement
Abstract Views :174 |
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Authors
Affiliations
1 Department of Medicine, Bharati Vidyapeeth University Medical College & Hospital, Pune - 411043, Maharashtra, IN
1 Department of Medicine, Bharati Vidyapeeth University Medical College & Hospital, Pune - 411043, Maharashtra, IN
Source
The Indian Practitioner, Vol 68, No 10 (2015), Pagination: 25-32Abstract
Objectives: To study and to classify spondyloarthropathies and to determine the cardiac involvement in patients with spondyloarthropathy (SpA) by ECG and echocardiography.
Material and Methods: A cross-sectional observational study was conducted on 38 patients diagnosed as having seronegative SpA over 12 months. Patients were selected using screening score for diagnosis, detailed history and examination (to exclude arthropathies secondary to trauma, congenital heart defects, cardiac surgeries, other connective tissue diseases), and serological tests to exclude rheumatoid arthritis. Patients who were included, were then subjected to historical and clinical evaluation (including joint examination, dermatological and ocular examination), laboratory and radiological investigations alongwith ECG and echocardiography. The data was compiled and analysed using statistical package for social sciences (SPSS v/s 18).
Results: Out of 38 patients, male to female ratio was 2.45:1; 31.6% belonged to 21-30 years age group. 68.4% had symptoms of spondyloarthropathy since 1-10 years. Ankylosing spondylitis was the commonest SpA ocurring in 73.7%. Occurrence of articular manifestations was 100%; main joint affected was sacro-iliac joint alongwith spine in 92.1% followed by knee joint (87%), then ankle, shoulder, wrist and elbow joint in decreasing order of frequency. As opposed to this, extra articular manifestations were seen in 39.0%. ECG abnormalities such as ST segment changes and rhythm disturbances were noted in 6 patients with aortic regurgitation. ESR and CRP were raised in 90%. Echocardiography was normal in 21%. Among the rest, mitral valve involvement (prolapse, myxomatous valve, regurgitation) was highest (47.3%) followed by aortic valve (regurgitation, thickening, bicuspid aortic valve).
- Correlation of Carotid Intima Media Thickness (As a Marker of Atherosclerosis) with Inflammatory Markers, Disease Activity and Duration of Rheumatoid Arthritis
Abstract Views :171 |
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Authors
Affiliations
1 Department of Medicine and Rheumatology, Bharati Vidyapeeth Deemed University and Medical College, Pune, IN
1 Department of Medicine and Rheumatology, Bharati Vidyapeeth Deemed University and Medical College, Pune, IN
Source
The Indian Practitioner, Vol 69, No 6 (2016), Pagination: 55-58Abstract
No Abstract.References
- Gary SF, Raph CB, Edward D H. Kelly’s Textbook of Rheumatology ,8th Ed. Philadelphia, Saunders Elsevier 1981; Atherosclerosis in Rheumatoid Arthritis:421-4280
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- Rantapää-Dahlqvist S, de Jong BA, Berglin E et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741
- Grover S, Sinha RP, Singh U, Tewari S Agarwal A, Misra R N. Subclinical atherosclerosis in RA in India. J Rheumatol.2006;33:244-47.
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- Kerekes G, Szekanecz Z, Dér H et al. Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity. J Rheumatol. 2008;35:398-406.
- H Singh, Mukesh Goyal, J Sen, Harish Kumar, Rahul Handa, Susheel Garg. Correlation of Intima Media Thickness (as a Marker of Atherosclerosis) with Activity and Duration of Rheumatoid Arthritis using Carotid Ultrasound. JIACM. 2011;12(1):15-20.
- Mahajan V, Handa R, Kumar U, Sharma S, Gulati G, Pandey RM et al. Assessment of atherosclerosis by carotid intimomedial thickness in patients with rheumatoid arthritis. JAPI. 2008;56:587-90.
- Gonzalez-Juanatey C, Llorca J. Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis. Semin Arthritis Rheum. 2009;38(5):366-71.
- Del Rincon I, Williams K, Stern MP, Freeman GL. Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects. Arthritis Rheum. 2003;48(7):1833-40.
- Skeoch S, Ian Bruce I. Atherosclerosis in rheumatoid arthritis; nature reviews Rheumatology. 2015;11:390-400.
- Gupta N, Saigal R.Carotid Intima Media Thickness as a Marker of Atherosclerosis in Ankylosing Spondylitis. International Journal of Rheumatology. Volume 2014 (2014), Article ID 839135.
- Valproate Causing Recurrent Acute Pancreatitis
Abstract Views :214 |
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Authors
Affiliations
1 Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, IN
2 Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, IN
1 Dept. of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, IN
2 Dept, of Medicine, Bharati Vidyapeeth Deemed University Medical College and Hospital, Pune, Maharashtra, IN
Source
The Indian Practitioner, Vol 70, No 8 (2017), Pagination: 36-38Abstract
Valproic acid is used either as monotherapy or in combination with other anticonvulsants for the treatment of simple, mixed and complex partial seizures, myoclonic seizure, generalised tonic- clonic seizure, acute manic episodes in bipolar disorder, and for prophylaxis of migraine headaches. The association of sodium valproate and pancreatitis is sometimes referred to as idiosyncratic as pancreatitis can develop after 1 week to 8 years of exposure to sodium valproate. We report a case of 39 year old male known case of seizure disorder presenting with recurrent episodes of epigatrium and right hypochondrium abdominal pain associated with vomiting over a period of 4 years. After excluding other causes of pancreatitis, a diagnosis of valproate induced necrotising pancreatitis was established.Keywords
Valproic Acid, Pancreatitis.References
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- Idiosyncratic adverse reactions to antiepileptic drugs. Zaccara G, Franciotta D, Perucca E. Epilepsia.2007;48:1223–1244.
- Gerstner T, Büsing D, Bell N. et al. Valproic acidinduced pancreatitis:16 new cases and a review of the literature. J Gastroenterol. 2007;42(1):39–48.
- Wilmink T, Frick WK. Drug induced pancreatitis. Drug safety 1996; 14: 406-423.
- Pancreatitis associated with valproic acid therapy. Batalden PB, Van Dyne BJ, Cloyd J. Pediatrics.1979;64:520–522.
- Pancreatitis due to valproic acid. Camfield PR, Bagnell P, Camfield CS, Tibbles JA. Lancet. 1979;1:1198–1199.
- Hamad AE, Fawzi ME. Valproate associated acute pancreatitis. Neurosciences. 2000;5(3):156–8.
- The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis. Sanfey H, Bulkley GB, Cameron JL. Ann Surg. 1984;200:405– 413.
- Acute pancreatitis coincident with valproate use: a critical review. Pellock JM, Wilder BJ, Deaton R, Sommerville KW. Epilepsia. 2002;43:1421–1424.
- Carnitine levels in valproic acid-treated psychiatric patients: a cross-sectional study. Moreno FA, Macey H, Schreiber B. J Clin Psychiatry. 2005;66:555–558.
- The spectrum of valproic acid-associated pancreatitis. Werlin SL, Fish DL. Pediatrics. 2006;118:1660– 1663.