Open Access
Subscription Access
Open Access
Subscription Access
Application of Transgenic Mosquitoes as an Alternative Vector Control Strategy
Subscribe/Renew Journal
Mosquitoes are infamous creatures responsible for spreading many life-threatening diseases throughout the world. Prolonged use of chemical insecticides for mosquito control resulted in the emergence of some insecticide resistant varieties. Other vector control methods such as mechanical and biological processes could not impact much in restricting mosquito populations on a large scale. Hence, it was necessary to develop an alternative, eco-friendly mosquito control method. Genetic control of mosquitoes or application of transgenic mosquitoes may be a suitable strategy in this regard. It is the most promising new generation mosquito control method that has already started to be implemented in many parts of the world, with considerable success. The main objective of the present communication is to review different strategies of genetic control of mosquitoes, molecular methods to develop transgenic mosquitoes, field trials, limitations, and future aspects of using transgenic mosquitoes as a potential mosquito control strategy.
Keywords
Genetic Control, Mosquitoes, Population Suppression, Sterile Insect Technique, Transgenic Mosquitoes.
User
Subscription
Login to verify subscription
Font Size
Information
- P Leisnham, Taking a bite out of mosquito research. University of Maryland (https://enst.umd.edu/news/taking-bite-out-mosquito-research)
- Biological notes on mosquitoes (https://web.archive.org/web/20030805155738/http://www.mosquitoes.org/LifeCycle.html)
- L O’Connor, C Plichart, AC Sang, CL Brelsfoard, HC Bossin, SL Dobson, Open release of male mosquitoes infected with a Wolbachia biopesticide: field performance and infection containment, PLoSNegl Trop Dis, Vol6, e1797, 2012.
- M Ramírez-Lepe, M Ramírez-Suero, Biological control of mosquito larvae by Bacillus thuringiensis subsp. Israelensis, In: Insecticides -Pest Engineering. Perveen F (ed.); Rijeka, Croatia: Intech, page 239-64, 2012.w of Entomology
- J B Kitzmiller, 1972, Genetic control of mosquitos, Am J Trop Med Hyg,Vol21, No 5, page 764-771.
- E Knipling, Possibilities of insect control or eradicationthrough the use of sexually sterile males, J Econ Entomol,Oxford academics, vol48, page459-69, 1955.
- M E Helinski,A G Parker, BG Knols,Radiation biology of mosquitoes,Malar J,8 (Suppl 2): S6, 2009. indbichler,PA Papathanos,A Crisanti, Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae. PLoS Genet. Vol4, No 12:e100029.
- L Alphey, D Nimmo. S O’Connell, N Alphey, Insect population suppression using engineered insects, In: Transgenesis and the Management of VectorBorne Disease. Vol 627, page 93-103, 2008.
- HK Phucet al, Late-acting dominant lethal genetic systems and mosquito control, BMC Biol,Vol 5, page11.2007.
- P Schliekelman, F Gould, Pest control by the release of insects carrying a female-killing allele on multiple loci, J Econ Entomol,Vol93, No 1, Page 566-579, 2000.
- A Burt,Site-specific selfish genes as tools for the control and genetic engineering of natural populations, ProcBiolSci,Vol270, page921-928, 2003.
- A Deredec,A Burt, H Godfray,Population genetics of using homing endonuclease genes in vector and pest management, Genetics, Vol 179, page2013-26, 2008.
- JH Werren,L Baldo,ME Clark, Wolbachia: master manipulators of invertebrate biology, Nat Rev Microbiol,Vol6 page741-51,2008
- L Alphey,Genetic control of mosquitoes.Annu Rev Entomol,Vol59, page205-24, 2014.
- N Sethuraman, MJ Fraser, P Eggleston, DO’Brochta, Post-integration stability of piggyBac in Aedesaegypti, Insect BiochemMolBiol, Vol 37, page941-951, 2007.
- CH Chenet al, A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila, Science,Vol316 page:597-600, 2007.
- J M Marshall,C E Taylor, Malaria control with transgenic mosquitoes,PLoSMed. Vol 6, No 2, e1000020, 2009.
- F Gould,Y Huang,M Legros,A LLloyd,A killerrescue system for self-limiting gene drive of antipathogen constructs, ProcBiolSci, Vol 275, No 1653, page 2823-2829, 2008.
- I Bargielowski, DNimmo,LAlphey, J CKoella, Comparison of life history characteristics of the genetically modified OX513A line and a wild type strain of Aedesaegypti, PLoS One.Vol6:e20699, 2011.
- R Lacroixet al,Open field release of genetically engineered sterile male Aedesaegypti in Malaysia,PLoS One,Vol 7, e42771, 2012.
- K CCondonet al. Genetic sexing through the use of Y-linked transgenes, Insect BiochemMolBio,Vol37, page1168-76,2007.
- D Mercer, Future Revolutions: Unravelling the Uncertainties of Life and Work in the 21st Century, London: Orion Business Books,1998.
Abstract Views: 403
PDF Views: 3