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Emergence of Oligonucleotide Drugs


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1 Sarojini Naidu College for Women, 30 Jessore Road, Kolkata, West Bengal, India
     

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Identification of DNA as hereditary material together with the revelation of double helical structure of DNA laid the foundation for understanding various diseases of genetic origin. Later on, with the report of non-aqueous chemical synthesis of genetic material, i.e., oligonucleotides, and discovery of solid phase synthesis, possibilities to produce custom design pieces of genetic material in large quantity, in reasonable time frame and in cost-effective manner emerged. This paved the path for nucleic acid based therapeutics. As technology matured, several oligonucleotide drugs got green signals from FDA during last decade. Waylivra® and Givlaari® are the latest additions.

Keywords

DNA, Oligonucleotide, Therapeutics, Antisense, siRNA.
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  • Emergence of Oligonucleotide Drugs

Abstract Views: 358  |  PDF Views: 0

Authors

Jharna Barman Nandi
Sarojini Naidu College for Women, 30 Jessore Road, Kolkata, West Bengal, India

Abstract


Identification of DNA as hereditary material together with the revelation of double helical structure of DNA laid the foundation for understanding various diseases of genetic origin. Later on, with the report of non-aqueous chemical synthesis of genetic material, i.e., oligonucleotides, and discovery of solid phase synthesis, possibilities to produce custom design pieces of genetic material in large quantity, in reasonable time frame and in cost-effective manner emerged. This paved the path for nucleic acid based therapeutics. As technology matured, several oligonucleotide drugs got green signals from FDA during last decade. Waylivra® and Givlaari® are the latest additions.

Keywords


DNA, Oligonucleotide, Therapeutics, Antisense, siRNA.

References





DOI: https://doi.org/10.24906/isc%2F2020%2Fv34%2Fi6%2F208219