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Effect of Selenium, Glutathione S-transferase, Glucose-6-phosphate Dehydrogenase and Lipid Peroxidation in Streptozoticin Induced Diabetic Rats


Affiliations
1 Division of Biochemistry, Department of Phamaceutical Technology Jadavpur University, India
2 Division of Biochemistry, Department of Phamaceutical Technology Jadavpur University
     

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Biochemical measurements of specific components of blood, specific enzyme assays and estimation of selenium (Se) content of normal and diabetes induced rats, serve as important indicators of the metabolic state. These help in diagnosing disease and in reigulating treatment. In streptozoticin treated animals there is a tremendous rise in the levels of blood sugar, Se content and also a marked increase in the rates of lipid peroxidation. The activity of the enzyme G-S-transferase was noticeably higher. However G-6-p dehydrogenase activity showed a steady decline.

Keywords

Streptozoticin, Selenocysteine
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  • W H Habig, M J Pahst and W B Jakoby, J Biol Cliem 249, 7130-7139, 1979.


Abstract Views: 146

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  • Effect of Selenium, Glutathione S-transferase, Glucose-6-phosphate Dehydrogenase and Lipid Peroxidation in Streptozoticin Induced Diabetic Rats

Abstract Views: 146  |  PDF Views: 0

Authors

Sukanya Bhattacharya
Division of Biochemistry, Department of Phamaceutical Technology Jadavpur University, India
Anupam Bishayee
Division of Biochemistry, Department of Phamaceutical Technology Jadavpur University
J R Mukherjee
Division of Biochemistry, Department of Phamaceutical Technology Jadavpur University

Abstract


Biochemical measurements of specific components of blood, specific enzyme assays and estimation of selenium (Se) content of normal and diabetes induced rats, serve as important indicators of the metabolic state. These help in diagnosing disease and in reigulating treatment. In streptozoticin treated animals there is a tremendous rise in the levels of blood sugar, Se content and also a marked increase in the rates of lipid peroxidation. The activity of the enzyme G-S-transferase was noticeably higher. However G-6-p dehydrogenase activity showed a steady decline.

Keywords


Streptozoticin, Selenocysteine

References