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Association Between Circulating Inflammatory and Anti-Inflammatory Proteins and Risk of Development of Type II Diabetes Mellitusin Indian Obese Children


Affiliations
1 Department of Physiology, King George’s Medical University, Lucknow (U.P.), India
2 Department of Paediatrics, King George Medical University, Lucknow (U.P.), India
3 Department of Biochemistry, King George Medical University, Lucknow (U.P.), India
     

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Background and aim: Anti-inflammatory IL-10, omentin-1 and inflammatory visfatin dysregulation play a role in the development of metabolic syndrome. The objective of this study was to evaluate the association between circulating IL-10, omentin-1 and visfatin concentration and risk of development of type II diabetesin obese with MS children.Methods:Total of 220 obese were enrolled in our case-control study. They were divided according to NCEP ATP III criteria into obese without MS (control) and obese with MS (case) based on their BMI-percentile, obese children subdivided into overweight, obese, severally obese on the basis of BMI (percentile). Fasting blood sample was collected to determine biochemical parameters. Serum IL-10, omentin-1and visfatin plasma level was assessed by ELISA kit method. Association of these proteins with biochemical and anthropometric parameters were studied. Results: Obese children with MS showed a borderline significant decrease in serum IL-10 levels, Omentin-1 levels however, significantly increased in visfatin levels as compared to without MS obese children. In correlation analysis, we found all the three proteins were significantly corelated with BMI (percentile) but visfatin was also corelated with fasting plasma glucose. Interpretation and conclusions: Our study supports the hypothesis that abnormal production of IL- 10, omentin-1 and visfatin may contribute to the development of obesity in children, the correlation between MS and the BMI (percentile) may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI (percentile) for MS is an important factor for establishing an early diagnosis of diabetes.Risk of development of MS may be a diagnostic parameter for obesity-related complications such as Type II DM.

Keywords

Interleukin 10, Type II Diabetes Mellitus, HOMA-IR, Obesity, Omentin- 1, Visfatin.
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  • Midha, T., Nath, B., Kumari, R., Rao, Y.K. and Pandey, U. (2012). Childhood obesity in India: a meta-analysis. Indian J. Pediatrics., 79(7) : 945-948.DOI:10.1007/s12098-011-0587-6.

  • Bai, H., Jing, D., Guo, A. and Yin, S. (2014). Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population. J. Internat. Med.l Res., 42 (3) :702-10.DOI: 10.1177/0300060513505813.

  • Chang, Y.C., Chang, T.J., Lee, W.J. and Chuang, L.M. (2010). The relationship of visfatin/pre–B-cell colonyenhancing factor/nicotinamide phosphoribosyltransferase in adipose tissue with inflammation, insulin resistance, and plasma lipids. Metabolism-Clinical & Exp., 59 (1): 93-99. DOI: https://doi.org/10.1016/j.metabol.2009.07.011.

  • Arslan, N., Erdur, B. and Aydin, A. (2010). Hormones and cytokines in childhood obesity. Indian Pediatr.,47(10):829839.

  • Scarpelli, D., Cardellini, M., Andreozzi, F., Laratta, E., Hribal, M.L., Marini, M.A., Tassi, V., Lauro, R., Perticone, F. and Sesti, G. (2006). Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in Caucasian Italian subjects. Diabetes.,55(5):1529-1533. https://doi.org/10.2337/db06-0047.

  • Esposito, K., Pontillo, A., Giugliano, F., Giugliano, G., Marfella, R., Nicoletti, G. and Giugliano, D. (2003). Association of low interleukin-10 levels with the metabolic syndrome in obese women. J.Clinical Endocrinol. & Metabolism, 88 (3):1055-8. https://doi.org/10.1210/jc.2002021437.

  • Pan, H.Y., Guo, L. and Li, Q. (2010). Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Res. & Clinic. Practice, 88(1):29-33. DOI:10.1016/j.diabres.2010.01.013.

  • De, Souza, Batista, C.M., Yang, R.Z., Lee, M.J., Glynn, N.M., Yu, D.Z., Pray, J., Ndubuizu, K., Patil, S., Schwartz, A., Kligman, M. and Fried, S.K. (2007). Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 56(6):1655-1661. https://doi.org/10.2337/db06-1506.

  • Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S. and McNiece, I. (1994). Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Molecular &Cellular Biology,14(2):1431-1437.doi: 10.1128/ MCB. 14.2.1431.

  • Jia, S.H., Li, Y., Parodo, J., Kapus, A., Fan, L., Rotstein, O.D. and Marshall, J.C. (2004). Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J.Clinic. Investig., 113 (9): 1318-27.doi:10.1172/JCI19930.

  • Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H. and Watanabe, E. (2005).Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science, 307 (5708):426-30.DOI: 10.1126/science. 1097243.

  • Hug, C. and Lodish, H.F. (2005).Visfatin: a new adipokine. Science., 307 (5708) : 366-367.DOI: 10.1126/science.1106933.

  • Jacques, C., Holzenberger, M., Mladenovic, Z., Salvat, C., Pecchi, E., Berenbaum, F. and Gosset, M. (2012). Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. J. Biological Chem., 287(18):15100-8.doi: 10.1074/jbc.M112. 350215.

  • Sen, Y., Kandemir, N., Alikasifoglu, A., Gonc, N. and Ozon, A. (2008). Prevalence and risk factors of metabolic syndrome in obese children and adolescents: the role of the severity of obesity. European J. Pediatrics, 167(10):1183-1189.doi: 10.1007/s00431-007-0658-x.

  • Cole, T.J., Bellizzi, M.C., Flegal, K.M., Dietz, W.H. (2000). Establishing a standard definition for child overweight and obesity worldwide: Internat. Survey Bmj.,320 (7244):1240. doi: https://doi.org/10.1136/bmj.320.7244.1240.

  • Tedgui, A. and Mallat, Z.(2001). Anti-inflammatory mechanisms in the vascular wall. Circulation Res., 88(9):87787. http://doi.org/10.1161/hh0901.090440.

  • Yudkin, J.S., Stehouwer, C., Emeis, J. and Coppack, S. (1999). C-reactive protein in healthy subjects: associations with obesity, insulin resistance and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis, Thrombosis &Vascular Biology,19 (4):972978. https://doi.org/10.1161/01.ATV.19.4.972.

  • Kulshrestha, H., Gupta, V., Mishra, S., Mahdi, A.A., Awasthi, S. and Chaudhry, S. (2018). Interleukin-10 as a novel biomarker of metabolic risk factors. Diabetes & Metabolic Syndrome: Clinical Research & Reviews., 2018 Mar 27. https://doi.org/10.1016/j.dsx.2018.03.019.

  • Ohashi, K., Shibata, R., Murohara, T. and Ouchi, N. (2014).Role of anti-inflammatory adipokines in obesity-related diseases. Trends in Endocrinology & Metabolism, 25 (7) : 348-55.https://doi.org/10.1016/j.tem.2014.03.009.

  • Shibata, R., Ouchi, N., Kikuchi, R., Takahashi, R., Takeshita, K., Kataoka, Y., Ohashi, K., Ikeda, N., Kihara, S. and Murohara, T. (2011). Circulating omentin is associated with coronary artery disease in men. Atherosclerosis, 219(2):811-814.DOI: https://doi.org/10.1016/j. atherosclerosis. 2011.08.017.

  • Abd-Elbaky, A.E., Abo-ElMatty, D.M., Mesbah, N.M. and Ibrahim, S.M. (2015). Associations of serum omentin and apelin concentrations with obesity, diabetes mellitus type 2 and cardiovascular diseases in Egyptian population. Endocrinol. Metab. Synd.,4:171.doi:10.4172/2161-1017. 1000171.

  • Moreno-Navarrete, J.M., Catalan, V., Ortega, F., GomezAmbrosi, J., Ricart, W., Fruhbeck, G. and Fernandez-Real, J.M.(2010). Circulating omentin concentration increases after weight loss. Nutrition &Metabolism.,7(1):27. https://doi.org/ 10.1186/1743-7075-7-27.

  • Chen, M.P., Chung, F.M., Chang, D.M., Tsai, J.C., Huang, H.F., Shin, S.J. and Lee, Y.J. (2006). Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J. Clinic. Endocrinol. & Metabolism, 91(1): 295-299.https://doi.org/10.1210/jc.2005-1475.

  • Sun, G., Bishop, J., Khalili, S., Vasdev, S., Gill, V., Pace, D., Fitzpatrick, D., Randell, E., Xie, Y.G. and Zhang, H. (2007). Serum visfatin concentrations are positively correlated with serum triacylglycerols and down-regulated by overfeeding in healthy young men. American J. Clinic. Nutr., 85(2):399404. https://doi.org/10.1093/ajcn/85.2.399.

  • Van Exel, E., Gussekloo, J., De Craen, A.J., Frölich, M., Bootsma-van, der Wiel, A. and Westendorp, R.G. (2002). Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes: the Leiden 85-Plus Study. Diabetes., 51(4):1088-1092.https://doi.org/10.2337/ diabetes.51.4.1088.


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  • Association Between Circulating Inflammatory and Anti-Inflammatory Proteins and Risk of Development of Type II Diabetes Mellitusin Indian Obese Children

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Authors

Himani Kulshrestha
Department of Physiology, King George’s Medical University, Lucknow (U.P.), India
Vani Gupta
Department of Physiology, King George’s Medical University, Lucknow (U.P.), India
Sameeksha Mishra
Department of Physiology, King George’s Medical University, Lucknow (U.P.), India
Supriya Mishra
Department of Physiology, King George’s Medical University, Lucknow (U.P.), India
Shelly Awasthi
Department of Paediatrics, King George Medical University, Lucknow (U.P.), India
Abbas Ali Mahdi
Department of Biochemistry, King George Medical University, Lucknow (U.P.), India

Abstract


Background and aim: Anti-inflammatory IL-10, omentin-1 and inflammatory visfatin dysregulation play a role in the development of metabolic syndrome. The objective of this study was to evaluate the association between circulating IL-10, omentin-1 and visfatin concentration and risk of development of type II diabetesin obese with MS children.Methods:Total of 220 obese were enrolled in our case-control study. They were divided according to NCEP ATP III criteria into obese without MS (control) and obese with MS (case) based on their BMI-percentile, obese children subdivided into overweight, obese, severally obese on the basis of BMI (percentile). Fasting blood sample was collected to determine biochemical parameters. Serum IL-10, omentin-1and visfatin plasma level was assessed by ELISA kit method. Association of these proteins with biochemical and anthropometric parameters were studied. Results: Obese children with MS showed a borderline significant decrease in serum IL-10 levels, Omentin-1 levels however, significantly increased in visfatin levels as compared to without MS obese children. In correlation analysis, we found all the three proteins were significantly corelated with BMI (percentile) but visfatin was also corelated with fasting plasma glucose. Interpretation and conclusions: Our study supports the hypothesis that abnormal production of IL- 10, omentin-1 and visfatin may contribute to the development of obesity in children, the correlation between MS and the BMI (percentile) may be an effective parameter in identifying obese children and adolescents at risk for MS. Screening the cases with BMI (percentile) for MS is an important factor for establishing an early diagnosis of diabetes.Risk of development of MS may be a diagnostic parameter for obesity-related complications such as Type II DM.

Keywords


Interleukin 10, Type II Diabetes Mellitus, HOMA-IR, Obesity, Omentin- 1, Visfatin.

References