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Thomas, Anooja
- Impact of Homocysteine and Calcium Score Levels on the Risk Assessment of Percutaneous Transluminal Coronary Angioplasty (PTCA) Undergone Patients
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Authors
R. Dhanya
1,
Anooja Thomas
2
Affiliations
1 Department of Home Science, St. Teresa's College, Ernakulam (Kerala), IN
2 Department of Home Science, CMS College, Kottayam (Kerala), IN
1 Department of Home Science, St. Teresa's College, Ernakulam (Kerala), IN
2 Department of Home Science, CMS College, Kottayam (Kerala), IN
Source
International Journal of Medical Sciences, Vol 10, No 1-2 (2017), Pagination: 1-6Abstract
Cardio-vascular disease is increasing its pace day by day and is the leading cause of mortality and morbidity. Though the traditional biomarkers are made available, the novel biomarkers are been incorporated to predict the risk of cardio-vascular diseases for early detection. The present study aimed to investigate the impact of C-reactive protein and calcium score levels in the risk assessment of percutaneous transluminal coronary patients. Four hundred cardio-vascular patients selectively males were randomly selected from Visakhapatnam district Andhrapradesh. Information on economic background, anthropometric measurements, diet history, life style habit and medical history of the subjects were collected using an interview schedule. All the subjects were screened to know they are on medical management or on surgical management. Data collected were consolidated and tabulated. Among the four hundred subjects 220 subjects were found to undergo PTCA. From this group a sub sample of 50 patients were selected and analyzed for their lipid profile, C-reactive protein, serum albumin, homocystiene and calcium score levels before and after PTCA. Statistical analysis was done and interpreted. Even though a wide variety of biomarkers were available for assessing the risk of coronary artery disease subjects, C-reactive protein and calcium score levels were found to be the most significant biomarkers to predict the risk of cardio-vascular diseases. The present study identified these two parameters as the most predictive biomarkers among the usual clinical investigations conducted for the clinicians to predict the severeness of the cardio-vascular disease and to correct the scenario with PTCA.Keywords
Coronary Artery Disease, PTCA, Biomarkers, Homocysteine, C-Reactive Protein, Calcium Scores.
References
- Azevedo, C.F., Rochitte, C.E. and Lima, J.A. (2012). Coronary artery calcium score and coronary computed tomographic angiography for cardio-vascular risk stratification, Arq. Bras. Cardiol., 98(6) : 559-68.
- Bamba, V. (2014). Update on screening, etiology and treatment of dyslipidemia in children. J. Clinic. Endocrinol. & Metabol., 99 (9) : 3093-3102.
- Brown, T.M. and Bittner, V. (2008). Biomarkers of atherosclerosis: clinical applications, Current Cardiol. Reports, 10 (6) : 497-504.
- Brucker, N., Charao, M.F., Moro, A.M., Ferrari, P., Bubols, G., Sauer, E., Fracasso, R., Durgante, J., Thiesen, F.V., Duarte, M.M., Gioda, A., Castro, I., Saldiva, P.H. and Garcia, S.C.(2014). Atherosclerotic process in taxi drivers occupationally exposed to air pollution and co-morbidities. Environ Res., 131: 31-38.
- Centers for Disease Control and Prevention (2000). Laboratory procedure manual, total homocysteine in plasma, pp.25-29.
- Deepak, A.R., Tao, L. and Bhushan, V. (2007). First aid for the USMLE step 1 2008 (First Aid for the Usmle Step 1). McGraw-Hill Medical, ISBN, 7 : 149868-149870.
- Harjai, K.J. (1999). Potential new cardio-vascular risk factors: Left ventricular hypertrophy, homocysteine, lipoprotein (a), triglycerides, oxidative stress and fibrinogen, Ann. Intern. Med, 131(5) : 376.
- Indrayan, A. (2005). Forecasting vascular disease cases and associated mortality in India. Reports of the National Commission on Macroeconomics and Health, Ministry of Health and Family Welfare, India, pp.24.
- Ishikawa, T., Hatakeyama, K., Imamura, T., Date, H., Shibata, Y., Hikichi, Y. and Asada, Y. (2003). Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris, Am. J. Cardiol., 91 : 287-292.
- Kumar, Praveen and Clark’s, Michael (2012). Cardio-vascular Disease, Clinical Medicine, pp. 731.
- National Cholesterol Education Program (2001). Third report of the NCEP expert panel on detection, evaluation and treatment of high blood cholesterol in adults: Executive summary, NIH Pub No 013, pp.670.
- Parsi, A.F., Folland, E.D. and Hartigan, P.A.(1992). Comparison of angioplasty with medical therapy in the treatment of single vessel coronary artery disease. New England J. Medicine, 329 : 1-7.
- Rajeev, G. (2009). Coronary Heart Disease in Low Socioeconomic Status Subjects in India, Indian Heart J., 61: 358-367.
- Smith, S.C. Jr., Dove, J.T., Jacobs, A.K., Kennedy, J.W., Kereiakes, D., Kern, M.J., Kuntz, R.E., Popma, J.J., Schaff, H.V., Williams, D.O., Gibbons, R.J., Alpert, J.P., Eagle, K.A., Faxon, D.P., Fuster, V., Gardner, T.J., Gregoratos, G. and Russell, R.O. (2001). ACC/AHA Guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines: executive summary and recommendations). A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty). J. Am. Coll. Cardiol., 37 : 2215-2239.
- Srinivastava, S. (2003). Coronary calcium and coronary artery disease: an Indian perspective. Indian Heart J., 55 : 344-348.
- Strickland, D.K., Cunfer, P. and Muratoglu, S.C. (2014).Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity, Arteriosclerosis, Thrombosis & Vascular Biology, 34 (3) : 487-498.
- Yeh, E.T.H. and Willerson, J.T. (2003). Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation, 107 : 370-372.
- Youssef, G. and Budoff, M.J. (2012). Coronary artery calcium scoring, what is answered and what questions remain. Cardiovasc. Diagn Ther, 2 (2) : 94-105.