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Authors
Affiliations
1 Department of Biochemistry, Melmaruvathur
Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), IN
Source
International Journal of Medical Sciences, Vol 4, No 1-2 (2011), Pagination: 7-9
Abstract
The background evidence of the association between H. pylori and peptic ucler is reviewed, together with methods of diagnosing H. pylori infection. Serological testing is considered to be simple, cheap and effective. At least one authority considers serological tests for H. pylori to be the "gold standard" against which all other should be measured. Helicobacter pylori (HP) are Gram negative spiral bacterial which occur in the muhan stomach. The bacteria were cultured in vitro for the first time in 1983, it is suspected that the bacteria may cause chronic gastritis of type B and may also be a contributory cause of chronic ulceration and cancer of the stomach. The bacteria are accompanied by characteristic inflammatory changes in the gastic mucosa. The significance for gastritis, chronic ulceration, non-ulcer dyspepsia and carcionoma of the stomach is discussed. Helicobacter pylori occurs in great proportion of the population of the world and the frequency increases with age. The route of infection is unknown but faecal-oral infection is probable. Our knowledge about the cause of peptic ulcer disease, of the aetiology of gastric cancer, and perhaps of some forms of dypepsia is in a state of revolution. The discovery of the infective organism Helicobacter pylori and its involvement in these diaseses has begun to change our views on how to approach diagnosis and treatment. Correlation between the presence of HP and occurrence of symptom is poor in the individual patient, the bacteria can be demonstrated histologically, cytological, by culture by the urease test, by the urease expiration test or serologically. The bacteria are sensitive for a series of antibiotics and bismuth but no effective treatment it known as the recurrence is high.
Keywords
Helicobacter pylori, Ulcer.
