International Journal of Medical Sciences

K. Satya Narayana ¹, Sravanthi Koora ², Ivvala Anand Shaker ³, S. Saleem Basha ³, K. Suresh Babu ³

Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), IN
2 Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar (A.P.), IN
3 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur (T.N.), IN

Abstract

Both diabetes and thyroid disorders involve dysfunction of the endocrine system. Almost one third of people with type 1 diabetes have been found to have thyroid disease. Since both diseases are parallel and influence one another. Any alteration in thyroid hormones may have further complication such as CAD. Low T₃ syndrome is well established in development of CAD. In the present study we assessed the circulating thyroid hormones and glycemic status among Diabetic population. T₃ levels are low in both Type I and II diabetes, and are directly correlated with poor glycemic control. Among the diabetic population women are worse affected than men. In conclusion, many diabetics showed a low T₃ levels, suggesting that there may be impairment in the extrathyroidal conversion of T₄ to T₃ (5' deiodinization) and in turn enhanced by a poor glycemic control. The study reveals that frequent checkup for thyroid hormones are compulsory to prevent further complications.

Keywords

Glycemic Status, Diabetes Mellitus, Thyroid Dysfunction, 5' Deiodinization, Low T₃ Syndrome, CAD.

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K. Satya Narayana ¹, Sravanthi Koora ², Inampudi Sailaja ³, Ivvala Anand Shaker ⁴

Affiliations
1 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), IN
2 Department of Pharmacology, Chalmeda Anand Rao Institute of Medical Sciences, Bommakal Karimanagar (T.N.), IN
3 Department of Biotechnology, College of Agricultural Biotechnology, Loni (M.S.), IN
4 Department of Biochemistry, Melmaruvathur Adhiparasakthi Institute of Medical Sciences, Melmaruvathur (T.N.), IN

Abstract

Free radicals especially the reactive oxygen species (ROS) implicated in etiology for over hundred diseases. Radiation is one of the major exogenous sources of free radicals in man and it has been proved that ionizing radiation produces ROS in biological system capable of destroying biomolecules. The objective of this study was to measure the serum antioxidant status level in health workers, to estimate the oxidative stress in red blood cells of radiographers by measuring the malondialdehyde (MDA) and percentage hemolysis of RBCs in comparison with controls, to determine the concentrations of antioxidants like vitamin E and catalase in the above groups, to determine the relationship between the levels of oxidative stress, antioxidants and the duration of occupational exposure in radiographers. 5ml of venous blood was collected in heparin. Plasma was used for estimation of vitamin E. The separated cells were used for the assay of oxidative stress parameters - malondialdehyde -oxidative hemolysis of RBS's (or) per cent of hemolysis of RBC, antioxidant status parameters- vitamin E and catalase. Present results show that the percentage of hemolysis of RBC was higher in, radiographers when compared with control group (p=0.0059). The RBC MDA (p=0.690), Catalase (p=0.050) and plasma vitamin 'E' levels (p=0.50) were higher in radiographers than in control group. Finally we can conclude that there is a mild increase in oxidative stress occurring as a result of chronic occupational exposure to low dose ionizing radiation.

Keywords

MDA, ROS, Vitamin E, Catalase and Oxidative Stress.

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