The Indian Journal of Nutrition and Dietetics

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Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 years) of Vallabh Vidyanagar, Anand, Gujarat


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1 Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
     

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Vitamin B<sub>12</sub> deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B<sub>12</sub> deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B<sub>12</sub> deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B<sub>12</sub> deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B<sub>12</sub> and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B<sub>12</sub> deficiency. The subjects were screened for their vitamin B<sub>12</sub> status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ≤ 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ≤ 0.05) relationship was observed between serum vitamin B<sub>12</sub> and iron levels (r = 0.127, P ≤ 0.05) of the subjects. In conclusion, vitamin B<sub>12</sub> status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration.

Keywords

Vitamin B12, Homocysteine, Total RBC, MCV, MCH, MCHC
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  • Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 years) of Vallabh Vidyanagar, Anand, Gujarat

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Authors

Revati Shah
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
Vinayak Patel
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
Neeta Dave
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India

Abstract


Vitamin B<sub>12</sub> deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B<sub>12</sub> deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B<sub>12</sub> deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B<sub>12</sub> deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B<sub>12</sub> and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B<sub>12</sub> deficiency. The subjects were screened for their vitamin B<sub>12</sub> status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ≤ 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ≤ 0.05) relationship was observed between serum vitamin B<sub>12</sub> and iron levels (r = 0.127, P ≤ 0.05) of the subjects. In conclusion, vitamin B<sub>12</sub> status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration.

Keywords


Vitamin B12, Homocysteine, Total RBC, MCV, MCH, MCHC

References