International Journal of Plant Sciences

Shabir Hussain ¹, Vikas Sharma ¹, Ajit Kumar Saxena ²

Affiliations
1 Division of Biochemistry and Plant Physiology, Faculty of Agriculture, Sher-e-kashmir University of Agricultural Sciences and Technology of Main Campus Chatha, Jammu, J&K, IN
2 Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Jammu, J&K, IN

Abstract

In vitro assay for cytotoxic activity of fruits obtained from Momordica charantia has been carried out against eight human cancer cell lines from six different tissues via methanolic and aqueous extract at the concentration of 100 g/ml. Results revealed that the 99 per cent methanolic extract suppressed the proliferation of seven human cancer cells. The most striking observations were 100 per cent growth inhibition against NCI-H322 (lung), 99 per cent growth inhibition against MCF-7 (breast) and 97 per cent growth inhibition on COLO-205 (colon) cancer cells. However, aqueous extract from the floral part of the plant showed activity (74%) against HCT-116 (colon). Based on the in vitro data, it is suggested that consumption of the components of this plant or ingestion of methanolic extract as tea may impart anticancer effects especially in the lung, breast, colon and will be evaluated for the possible isolation of active antitumor compounds.

Keywords

Momordica Charantia, Methanolic Extract, in Vitro Cytotoxic, Cancer Cells

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