A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Barzeh, Hamed
- Design and Optimization of Controlled Drug Delivery System of Losartan Potassium
Authors
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 130-137Abstract
Purpose: The objective of the study was to develop microspheres of Losartan potassium as controlled drug delivery system by using various polymer (HPMC and Ethylcellulose), evaluating the relationship and influence of different content levels of HPMC, and Ethylcellulose, in order to achieve a zero order release of Losartan potassium.
Approach: Microspheres were prepared by solvent evaporation process. Release kinetics was evaluated by using United States Pharmacopoeia (USP) type I dissolution apparatus. The release mechanism of microspheres loaded with Losartan potassium was determined by fitting the data in Korsmeryer peppas equation. The regression coefficient values for Peppas model was found to be high, indicating adequate fitting. The 'n' value was ranged from 0.548 to 0.963 indicating Non Fickian diffusion for all the formulations. Optimization was performed by using desirability function. To validate the model, the optimized formula was subjected to in vitro characterization.
Findings: Release kinetics of Losartan potassium from these microspheres was principally regulated by HPMC K4M and Ethylcellulose. Percentage yield, entrapment efficiency and particle size of optimized formula was found to be 91.42%, 68.01% and 310μm. Formulation (F1) release at the end of 12 hours of dissolution studies was found to be 79.81%.
Conclusion: It can be concluded that Losartan potassium loaded microspheres could be successfully formulated by using HPMC 4KM and Ethylcellulose by solvent evaporation method to obtain maximum percentage yield, entrapment efficiency, desired particle size.
Keywords
Microspheres, Losartan Potassium, HPMC K4M, Ethylcellulose, Percentage Yield, Drug Content, Entrapment Efficiency.Full Text
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- A Review on Extended Release Matrix Tablet
Authors
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur, Hobli, Bangalore - 560035, IN
Source
Journal of Pharmaceutical Research, Vol 15, No 4 (2016), Pagination: 147-152Abstract
Purpose : The aim of the study was to explore the necessity, advantages and different techniques of extended release matrix tablet to achieve continuous delivery of drugs at predictable rate and reproducible kinetics for a preterm delivery and provide a therapeutic amount of a drug to the proper site of the body to achieve promptly and then maintain the desired drug concentration.
Approach: Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers like HPMC, guar gum, xanthan gum, pectin, chitosan etc.
Finding: The matrix controls the release rate of drug. Release retardants like HPMC can aid in extended release and thus they form core excipient of the formulation. The matrices used may be hydrophilic, hydrophobic, mineral, or biodegradable types. The drug release rate can be studied by in vitro dissolution studies. Some drugs that have been formulated as extended release matrix tablets are Ambroxol HCl, Clarithromycin, Indomethacin etc.
Conclusion: The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.
Keywords
Extended Release, Polymer, In Vitro Dissolution, Matrix Tablet.Full Text
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