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Recent Studies on the Drug Delivery of Nebulizers - A Review


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1 School of Mechanical Engineering, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai – 600127, Tamil Nadu, India
     

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This article provides a summary of some of the most current research on the delivery of drugs to the lungs, as well as a discussion of some of the limitations of these studies. Nebulizers have been in use for more than a century to deliver aerosolized drugs to patients suffering from respiratory disorders. Aerosol devices such as these are the best option for people who have trouble managing their inhalation. Because of the actuation required, pressurised Metered-Dose Inhalers (pMDI) and Dry Powder Inhalers (DPI) are unable to generate the necessary inspiratory flow required for successful aerosol drug delivery. Currently, we are looking into how the working mechanism of different nebulizers interacts with the physicochemical features of the formulations. We are looking into a wide range of devices, such as jet, ultrasonic, and vibrating-mesh nebulizers. In this study, the researchers hope to describe the many different types of nebulizers that are currently available on the market, evaluate their performance in aerosol drug delivery, and recommend treatment approaches for patients with chronic obstructive pulmonary disease.

Keywords

Aerosol, Atomizer, Computational Fluid Dynamics (CFD), Dew Size, Drug Delivery, Nebulization, Nebulizer.
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  • Recent Studies on the Drug Delivery of Nebulizers - A Review

Abstract Views: 228  |  PDF Views: 1

Authors

N. Vinoth
School of Mechanical Engineering, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai – 600127, Tamil Nadu, India
Lokavarapu Bhaskara Rao
School of Mechanical Engineering, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai – 600127, Tamil Nadu, India

Abstract


This article provides a summary of some of the most current research on the delivery of drugs to the lungs, as well as a discussion of some of the limitations of these studies. Nebulizers have been in use for more than a century to deliver aerosolized drugs to patients suffering from respiratory disorders. Aerosol devices such as these are the best option for people who have trouble managing their inhalation. Because of the actuation required, pressurised Metered-Dose Inhalers (pMDI) and Dry Powder Inhalers (DPI) are unable to generate the necessary inspiratory flow required for successful aerosol drug delivery. Currently, we are looking into how the working mechanism of different nebulizers interacts with the physicochemical features of the formulations. We are looking into a wide range of devices, such as jet, ultrasonic, and vibrating-mesh nebulizers. In this study, the researchers hope to describe the many different types of nebulizers that are currently available on the market, evaluate their performance in aerosol drug delivery, and recommend treatment approaches for patients with chronic obstructive pulmonary disease.

Keywords


Aerosol, Atomizer, Computational Fluid Dynamics (CFD), Dew Size, Drug Delivery, Nebulization, Nebulizer.

References