Journal of Surface Science and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Surface Modification of Magnetic Nanoparticles for Therapeutic Applications


Affiliations
1 Chemistry Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India
     

   Subscribe/Renew Journal


Interfacial chemistry plays a vital role in developing nanostructured materials for drug delivery, catalysis, sensors etc. Selective binding of specific functional groups on nanoparticle surfaces can be exploited for the creation of organic layers that are susceptible to external stimuli such as pH, temperature and ionic strength. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have emerged as attractive materials for cancer therapy as well as for delivery of various drug molecules. Surface modification of SPIONs with desired functional groups is considered as a prerequisite for their biomedical applications. Organic molecules such as amino acids, polymers and receptor molecules can be introduced on the surface of SPIONs to make them amenable to biomedical applications. This review summarizes some of the recent developments in the area of surface functionalization of SPIONs and their therapeutic applications, especially drug delivery, hyperthermia treatment of cancer as well as combination therapy involving hyperthermia and chemotherapy. In particular, the presence of amino acids or peptide shells on the surface of these particles makes them attractive materials for pH-responsive charge reversal. The pH dependent charge reversal feature is conducive for selective binding and release of ionic drug molecules. The future prospects in this direction are also discussed.
Subscription Login to verify subscription
User
Notifications
Font Size


  • J. Cheon, J.-H. Lee, Acc. Chem. Res., 41, 1630 (2008).

  • K. C. Barick, M. Aslam, P. V. Prasad, V. P. Dravid and D. Bahadur, J. Magn. Magn. Mater., 321, 1529 (2009).

  • H. Gu, K. Xu, C. Xu and B. Xu, Chem. Commun., 941(2006).

  • F. Hu, L. Wei, Z. Zhou, Y. Ran, Z. Li and M. Gao, Adv.Mater., 18, 2553 (2006).

  • S. Mornet, S. Vasseur, F. Grasset and E. Duguet, J. Mater.Chem., 14, 2161 (2004).

  • K. C. Barick, M. Aslam, Y.-P. Lin, D. Bahadur, P. V. Prasad and V. P. Dravid, J. Mater. Chem., 19, 7023 (2009). 32. M. Mahmoudi, S. Sant, B. Wang, S. Laurent and T. Sen, Adv.Drug Del. Rev., 63, 24 (2011).

  • G. M. Barratt, Pharma. Sci. Technol. Today, 3, 163 (2000).

  • J.-W. Yoo, N. Doshi and S. Mitragotri, Adv. Drug Deliv. Rev.,63, 1247 (2011).

  • G. Storm, S. Belliot, T. Daemen and D. Lasic, Adv. Drug Deliv. Rev., 17, 31 (1995).

  • O. Veiseh, J. W. Gunn and M. Zhang, Adv. Drug Deliv. Rev.,62, 284 (2010).

  • P. Tartaj and C. J. Serna, J. Am. Chem. Soc., 125, 15754 (2003).

  • M. L. Hans and A. M. Lowman, Curr. Opin. Solid State Mater. Sci., 6, 319 (2002).

  • F. Q. Hu, L. Wei, Z. Zhou, Y. L. Ran, Z. Li and M. Y. Gao, Adv. Mater., 18, 2553 (2006).

  • S. Chandra, K. C. Barick and D. Bahadur, Adv. Drug Deliv.Rev., 63, 1267 (2011).

  • N. Kohler, G. E. Fryxell, and M. Zhang, J. Am. Chem. Soc.,126, 7206 (2004).

  • P. Chandrasekharan, D. Maity, Y. Chang-Tong, C. Kai-Hsiang, J. Ding and F. Si-Shen, Biomater, 31, 5588 (2010).

  • Y.-C. Chiu and Y.-C. Chen, Anal. Lett., 41, 260 (2008).

  • J. Lee, T. Isobe and M. Senna, J. Coll. Interf. Sci., 1996, 490(177).

  • J. Xie, C. Xu, N. Kohler and Y. Hou, S. Sun, Adv. Mater., 19,3163 (2007).

  • N. Kohler, G. E. Fryxell and M. Zhang, J. Am. Chem. Soc.,126, 7206 (2004).

  • D. E. Owens and N. A. Peppas. Int. J. Pharm., 307, 93(2006).

  • C. Sun, K. Du, C. Fang, N. Bhattarai, O. Veiseh, F. Kievit,Z. Stephen, D. Lee, R. G. Ellenbogen, B. Ratner and M.

  • Zhang, ACSNano, 4, 2402 (2010).

  • W. Lin, M. C. Garnett, E. Schacht, S. S. Davis and L. Illum,Int. J. Pharm., 189, 161 (1999).

  • J. Xie, C. Xu, N. Kohler, Y. Hou and S. Sun, Adv. Mater. 19,3163 (2007).

  • S. Rana, K. C. Barick, N. V. Jadhav, B. N. Pandey and P. A Hassan. Dalton Trans., 43, 12263 (2014).

  • U. A Häfeli, J. S. Riffle, A. Carmichael-Baranauskas,L. Harris-Shekhawat, F. Mark, J. P. Dailey and D. Bardenstein,

  • Mol. Pharma. 6, 1417 (2009).

  • L. A. Harris, J. D. Goff, A. Y. Carmichael, J. S. Riffle, J. J. Harburn, T. G. St Pierre and M. Saunders, Chem. Mater.,

  • , 1367 (2003).

  • C. Sun, R. Sze and M. Q. Zhang, J. Biomed. Mater. Res. A, 78A, 550 (2006).

  • C. Sun, C. Fang, Z. Stephen, O. Veiseh, S. Hansen, D. Lee,R. G. Ellenbogen, J. Olson and M. Q. Zhang, Nanomed. 3,

  • (2008).

  • Y. Jun and J. Choi, J. Cheon, Chem. Commun., 1203,(2007).

  • F. Yu and V. C. Yang, J. Biomed. Mater. Res. A., 92, 1468(2010).

  • B. Crepon, J. J. Chytry and R. Kopecek, Biomater, 12, 550(1991).

  • E. H. Kim, H. S. Lee, B. K. Kwak and B. K. Kim, J. Magn.Magn. Mater., 289, 328 (2005).

  • R. M. Patil, P. B. Shete, N. D. Thorat, S. V. Otari, K. C. Barick,A. Prasad, R. S. Ningthoujam, B. M. Tiwale and S. H. Pawar,

  • J. Magn. Magn. Mater., 355, 22 (2014).

  • P. V. Finotelli, D. Da Silva, M. Sola-Penna, A. M. Rossi, M. Farina, L. R. Andrade, A. Y. Takeuchi and M. H. Rocha-

  • Leao, Coll. Surfaces B: Biointerf., 81, 206 (2010).

  • S. Theerdhala, D. Bahadur, S. Vitta, N. Perkas, Z. Zhong and A. Gedanken, Ultrason. Sonochem., 17, 730 (2009).

  • J. M. E. Khoury, D. Caruntu, C. J. O’Connor, K.-U. Jeong, S. Z. D. Cheng and J. Hu, J. Nanopart. Res., 9, 959 (2007).

  • S. R. Wan, Y. Zheng, Y. Q. Liu, H. S. Yan and K. L. Liu, J. Mater. Chem., 15, 3424 (2005).

  • M. S. Martina, J. P. Fortin, C. Menager, O. Clement, G. Barratt, C. Grabielle-Madelmont, F. Gazeau, V. Cabuil and

  • S. Lesieur, J. Am. Chem. Soc., 127, 10676 (2005).

  • Y. Sahoo, A. Goodarzi, M. T. Swihart, T. Y. Ohulchanskyy, N. Kaur, E. P. Furlani and P. N. Prasad, J. Phys. Chem. B,

  • , 3879 (2005).

  • R. M. Cornell and U. Schertmann, “The Iron Oxides: Structure, Properties, Reactions, Occurrence and Uses”, VCH

  • Publishers, Weinheim, Germany, 1996.

  • Y. Sahoo, H. Pizem, T. Fried, D. Golodnitsky, L. Burstein, C. N. Sukenik and G. Markovich, Langmuir, 17, 7907 (2001).

  • S. Nayak, H. Lee, J. Chmielewski and L. A. Lyon, J. Am. Chem. Soc., 126, 10258 (2004).

  • M. Mammen, S. K. Choi and G. M. Whitesides, Angew. Chem. Int. Ed., 37, 2754 (1998).

  • S. Nigam, K. C. Barick and D. Bahadur, J. Magn. Magn.Mater., 323, 237 (2011).

  • J. Liu, Z. Sun, Y. Deng, Y. Zou, C. Li, X. Guo, L. Xiong, Y. Gao, F. Li and D. Zhao, Angew. Chem. Int. Ed., 48, 5875

  • (2009).

  • S. Singh, K. C. Barick and D. Bahadur, J. Hazard. Mater.,192, 1539 (2011).

  • C. R. Vestal and Z. J. Zhang, J. Am. Chem. Soc., 124, 14312 (2002).

  • L. Maurizi, H. Bisht, F. Bouyer and N. Millot, Langmuir, 25,8857 (2009).

  • C. R. A. Valois, J. M. Braz, E. S. Nunes, M. A. R. Vinolo, E. C. D. Lima, R. Curi, W. M. Kuebler and R. B. Azevedo,

  • Biomater, 31, 366 (2010).

  • C. Yee, G. Kataby, A. Ulman, T. Prozorov, H. White, A. King, M. Rafailovich, J. Sokolov and A. Gedanken, Langmuir, 15,

  • (1999).

  • Y. Sahoo, H. Pizem, T. Fried, D. Golodnitsky, L. Burstein, C. N. Sukenik and G. Markovich, Langmuir, 17, 7907 (2001).

  • P. Sharma, S. Rana, K. C. Barick, C. Kumar, H. G. Salunke and P. A. Hassan, New J. Chem., 38, 5500 (2014).

  • K. C. Barick and P. A. Hassan, J. Coll. Interf. Sci. 369, 96(2012).

  • W. Stöber, A. Fink and E. J. Bohn, Coll. Interf. Sci., 26, 62(1968).

  • Y. Zhang, S. W. Y. Gong, L. Jin, S. M. Li, Z. P. Chen, M. Ma and N. Gu, Chinese Chem. Lett. 20, 969 (2009).

  • L. Wang, K. G. Neoh, E.-T. Kang and B. Shuter, Biomater,32, 2166 (2011).

  • Z. Xu, Y. Hou and S. Sun, J. Am. Chem. Soc., 129, 8698(2007).

  • D. K. Kim, M. Mikhailova, M. Toprak, Y. Zhang, B. Bjelke, J. Kehr and M. Muhammed, Nanopart. Mater., 704, 137

  • (2002).

  • I. Y. Goon, L. M. H. Lai, M. Lim, P. Munroe, J. J. Gooding and R. Amal, Chem. Mater., 21, 673 (2009).

  • U. Tamer, Y. Gündo?du, ?. H. Boyac and K. Pekmez, J. Nanopart. Res., 12, 1187 (2009).

  • C. Xu, B. Wang and S. Sun, J. Am. Chem. Soc., 131, 4216 (2009).

  • J. Van der Zee, Ann. Oncol., 13, 1173 (2002).

  • A. Tomitaka, T. Koshi, S. Hatsugai, T. Yamada and Y. Takemura, J. Magn. Magn. Mater., 323, 1398 (2011).

  • K. Hayashi, K. Ono, H. Suzuki, M. Sawada, M. Moriya, W. Sakamoto and T. Yogo, Chem. Mater., 22, 3768 (2010).

  • K. C. Barick, S. Singh, D. Bahadur, M. A. Lawande, D. P. Patkar and P. A. Hassan, J. Coll. Interf. Sci., 418, 120 (2014).

  • R. M. Patil, P. B. Shete, N. D. Thorat, S. V. Otari, K. C. Barick, A. Prasad, R. S. Ningthoujam, B. M. Tiwale and S. H. Pawar,

  • RSC Adv., 4, 4515 (2014).

  • B. Samanta, H. Yan, N. O. Fischer, J. Shi, D. J. Jerry and V. M. Rotello, J. Mater. Chem., 18, 1204 (2008).

  • J.-P. Fortin, C. Wilhelm, J. Servais, C. Ménager, J.-C. Bacri and F. Gazeau, J. Am. Chem. Soc., 129, 2628 (2007).

  • L. S. Goldstein, M. W. Dewhirst, M. Repacholi and L. Kheifets, Int. J. Hyperth., 19, 373 (2003).

  • C. S. S. R. Kumar and F. Mohammad, Adv. Drug Deliv. Rev.,63, 789 (2011).

  • N. K. Prasad, K. Rathinasamy, D. Panda and D. Bahadur, J. Mater. Chem., 17, 5042 (2007).

  • E. Munnier, S. Cohen-Jonathan, C. Linassier, L. Douziech-Eyrolles, H. Marchais, M. Soucé, K. Hervé, P. Dubois and I.Chourpa, Int. J. Pharm., 361, 170 (2008).

  • T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann and B.Von Rechenberg, J. Magn. Magn. Mater., 293, 483 (2005).

  • S. Rudge, C. Peterson, C. Vessely, J. Koda, S. Stevens andL. Catterall, J. Control. Rel., 74, 335 (2001).

  • E.-K. Lim, Y.-M. Huh, J. Yang, K. Lee, J. -S. Suh and S. Haam, Adv. Mater., 23, 2436 (2011).

  • G. Kong and M. W. Dewhirst, Int. J. Hyperthermia, 15, 345(1999).

  • T. S. Herman, Cancer Res., 43, 517 (1983).

  • Y. Itoh, Y. Yamada, Y. Kazaoka, T. Ishiguchi and N. Honda, Exp. Therapeutic Med., 1, 319 (2010).

  • P. Pradhan, J. Giri, F. Rieken, C. Koch, O. Mykhaylyk, M. Döblinger, R. Banerjee, D. Bahadur and C. Plank, J.

  • Control. Rel., 142, 108 (2010).

  • K. Hayashi, K. Ono, H. Suzuki, M. Sawada, M. Moriya, W. Sakamoto and T. Yogo, Appl. Mater. Interf., 2 (2010).

  • K. C. Barick, S. Singh, N. V. Jadhav, D. Bahadur, B. N. Pandey and P. A. Hassan, Adv. Funct. Mater. 22, 4975 (2012).

  • H. Maeda, J. Wu, T. Sawa, Y. Matsumura and K. Hori, J. Control. Rel., 65, 271 (2000).


Abstract Views: 384

PDF Views: 0




  • Surface Modification of Magnetic Nanoparticles for Therapeutic Applications

Abstract Views: 384  |  PDF Views: 0

Authors

K. C. Barick
Chemistry Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India
Suman Rana
Chemistry Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India
P. A. Hassan
Chemistry Division, Bhabha Atomic Research Centre, Mumbai – 400 085, India

Abstract


Interfacial chemistry plays a vital role in developing nanostructured materials for drug delivery, catalysis, sensors etc. Selective binding of specific functional groups on nanoparticle surfaces can be exploited for the creation of organic layers that are susceptible to external stimuli such as pH, temperature and ionic strength. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have emerged as attractive materials for cancer therapy as well as for delivery of various drug molecules. Surface modification of SPIONs with desired functional groups is considered as a prerequisite for their biomedical applications. Organic molecules such as amino acids, polymers and receptor molecules can be introduced on the surface of SPIONs to make them amenable to biomedical applications. This review summarizes some of the recent developments in the area of surface functionalization of SPIONs and their therapeutic applications, especially drug delivery, hyperthermia treatment of cancer as well as combination therapy involving hyperthermia and chemotherapy. In particular, the presence of amino acids or peptide shells on the surface of these particles makes them attractive materials for pH-responsive charge reversal. The pH dependent charge reversal feature is conducive for selective binding and release of ionic drug molecules. The future prospects in this direction are also discussed.

References





DOI: https://doi.org/10.17834/ijsstissst.v31i1-2.79932