Solid State Green Synthesis and Properties on Paracetamol-Phenobarbital Binary Drug System

Molecular interaction between nonsteroidal antiinflammatory drug (NSAID)/analgesic/antipyretic drug and antiepileptic drug was studied taking views effectiveness and enhanced pharmaceutical properties. The objective of the present communication is to highlight thermodynamic and interfacial investigation of paracetamol (PCM) and phenobarbital (PB) binary drugs. The value of integral excess Gibbs energy gE in the PCM-PB system shows the positive deviation from ideal behaviour. It refers stronger association between the molecules of same drug during formation of binary mix. The negative value of Gibbs free energy of mixing (ΔGM) suggests the mixing of parent drug in eutectic and non eutectic binary drug is spontaneous. The interfacial property of binary drugs has been determined by the help of interfacial energy (σ) and roughness parameter (α). The size of critical nucleus of binary drug at different undercoolings was in nano size is substantiated its great future for pharmaceutical industries.