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Experimental and Finite Element Analysis of Soft Nanopillars for Biomedical Applications


Affiliations
1 Department of Mechanical Engineering, Madanapalle Institute of Technology and Science, Madanapalle, Andhra Pradesh, India
     

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The main objectives of this work are i) synthesise low aspect ratio soft nanopillars of the non-uniform cross-sectional area (tapered) on a polymeric substrate and ii) Design of soft nanopillars applying finite element technique. In this work, the nano-pillars are developed on a flat elastomeric substrate using well-established ball indentation technique. Soft elastomeric nanopillars of height ranging from 50 nm to 500 nm are prepared. Finite element simulations are performed to understand the large deformation behaviour of the elastomer. Different parameters such as indenter diameter, the shape of the indenter and elastomer properties are considered to tune the nanopillar height and width. These high aspect ratio nanopillars on flat surfaces can find many potential applications in recent days. In particular, these nano-pillar surfaces can be efficiently applied in the biomedical fields such as cell mechanics studies and biosensors. In these studies, nanopillar devices are implemented as a means to study cell–substrate, and cell to cell interactions. The stiffness and the deflection characteristics of these nanopillars are extremely necessary for biomedical applications.

Keywords

Ball Indentation, Hyperplastic Membranes, Nanopillars, and Young’s Modulus.
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  • Tyagi, A; Tripathi, KM; Gupta, RK: Recent Progress in Micro-scale Energy Storage Devices and Future Aspects, 'J. Mater. Chem'. A 2015, 3, 22507–22541. doi:10.1039/C5TA05666G.

  • Nguyen, BH; Nguyen, VH: Promising applications of graphene and graphenebased nanostructures, 2016.

  • Li, W; Liu, J; Zhao, D: Mesoporous materials for energy conversion and storage devices, 'Nature Reviews Materials', vol. 1, no. 6, 2016, 1 - 17. doi:10.1038/natrevmats.2016.23.

  • Moyen, E; Hama, A; Ismailova, E; Assaud, L; Malliaras, G; Hanbücken, M; Owens, RM: Nanostructured conducting polymers for stiffness controlled cell adhesion, 'Nanotechnology'. 19 Feb, 2016, vol. 27, no. 7, 074001. doi: 10.1088/09574484/27/7/074001. Epub 2016 Jan 21. (2016).

  • Eui, H; Suh, K: Precise tip shape transformation of nanopillars for enhanced dry adhesion, (2012) 5375–5380. doi:10.1039/c2sm07440k.

  • Sitti, M: High Aspect Ratio Polymer Micro / Nano- Structure Manufacturing using Nanoembossing, Nanomolding and Directed Self-Assembly, 'IMECE2003-42787, 2003, 293-297, https://doi.org/10.1115/IMECE2003-42787.

  • Lee, S; Park, B; Kim, JS; Kim, TI: Designs and processes toward high-aspect-ratio nanostructures at the deep nanoscale : unconventional nanolithography and its applications, 'Nanotechnology', vol. 27, no. 47, 2016 Nov 25, 474001.

  • Lim, JH; Leem, JW; Yu, JS: Solar power generation enhancement of dye-sensitized solar cells using hydrophobic and antireflective polymers with nanoholes, 'RSC Advances', no. 75, 2015, 61284–61289. doi:10.1039/C5RA10269C.

  • Zuiddam, MR; Frenken, JWM; Fabrication of high-aspect-ratio silicon nanopillars for tribological experiments, 2017. doi:10.1117/1.JMM.14.4.044506.

  • Chen, Ming-Hung; Chuang, Yun-Ju; Tseng, Fan-Gang: Self-masked high- aspect-ratio polymer nanopillars, 'Nanotechnology', vol. 19, no. 50, 2008, doi:10.1088/09574484/19/50/505301.

  • Dinesh, Chandra; Capillary Force in High Aspect-Ratio Micropillar Arrays Capillary Force in High Aspect- Ratio Micropillar Arrays, 2009.

  • Jiang, Weitao; Wang, Lanlan; Liu, Hongzhong; Ma, Haoyun; Tian, Hongmiao; Chen, Bangdao; Shi, Yongsheng; Yina, Lei; Dinga, Yucheng: Bio-inspired directional high-aspect-ratio nanopillars: fabrication and actuation, RSC Adv. no. 79, 2014, 42002–42008. doi:10.1039/C4RA05427J.

  • del Campo, Aránzazu; Arzt, Eduard: Fabrication Approaches for Generating Complex Micro- and Nanopatterns on Polymeric Surfaces, 'Chemical Reviews', ACS Publications, 49, 2008.

  • Moberlychan, WJ; Ghose, D; Arai, H; Imamura, H: Focused ion beam fabrication of spintronic nanostructures : An optimization of the milling process, 2 0 1 0 . doi:10.1088/0957- 4484/21/14/145304.

  • M. Matschuk, E. Stem, C. Toward, Injection moulding of ultra-high aspect ratio nanostructures using coated polymer tooling, (n.d.). doi:10.1088/0960-1317/24/7/075019.

  • Sedore, Matthew P: Yielding Behaviour of Electron Beam Lithography and Focused Ion Beam Made Nanocrystalline Micro / Nanopillars, Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2016-09-30 16:22:18.869.

  • Acikgoz, Canet; Hempenius , Mark A; Huskens, Jurriaan; Vancso, G Julius: Polymers in conventional and alternative lithography for the fabrication of nanostructures, ' European Polymer Journal', vol. 47, 2011, 2033–2052. doi:10.1016/j.eurpolymj.2011.07.025.

  • Online, VA; Bae, W; Kwak, MK; Jeong, HE; Pang, C; Suh, Jeong K: Soft Matter, 2013, 1422– 1427. doi:10.1039/c2sm27323c.

  • Zamanzade, M; Rafael, J; Torrents, O; Motz, C; Barnoush, A: Materials Science & Engineering A Mechanical behavior of iron aluminides : A comparison of nanoindentation, compression, and bending of micropillars, 'Mater. Sci. Eng. A.' vol. 652, 2016, 370–376. doi:10.1016/j.msea.2015.11.088.

  • Gu, W; Loynachan, CN; Wu, Z; Zhang, Y; Srolovitz, DJ; Greer, JR: Size-Dependent Deformation of Nanocrystalline Pt Nanopillars, 2012. doi:10.1021/nl3036993.

  • Kumar, M; Kumar, V; Upadhyaya, P; Pugazhenthi, G: Fabrication of poly (methyl methacrylate) (PMMA) nanocomposites with modified nanoclay by melt intercalation,'Compos. Interfaces.' 6440 (2017) 1 – 1 4 . doi:10.1080/15685543.2014.961780.

  • Youssef, AM; Malhat, FM; Hakim, AAA; Dekany, I: Synthesis and utilization of poly (methylmethacrylate) nanocomposites based on modified montmorillonite, 'Arab. J. Chem', vol. 10, 2017, 631–642. doi:10.1016/j.arabjc.2015.02.017.

  • Charitidis, CA; Koumoulos, EP: Nanomechanical properties and nanoscale deformation of PDMS nanocomposites, 8011(2017).doi:10.1179/1743289810Y.0000000037.

  • Ilg, P; Stimuli-responsive hydrogels cross-linked by magnetic nanoparticles, 'Soft Matter.', vol. 9, 2013, 3465–3468. doi:10.1039/C3SM27809C.


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  • Experimental and Finite Element Analysis of Soft Nanopillars for Biomedical Applications

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Authors

G. Mallikarjunachari
Department of Mechanical Engineering, Madanapalle Institute of Technology and Science, Madanapalle, Andhra Pradesh, India

Abstract


The main objectives of this work are i) synthesise low aspect ratio soft nanopillars of the non-uniform cross-sectional area (tapered) on a polymeric substrate and ii) Design of soft nanopillars applying finite element technique. In this work, the nano-pillars are developed on a flat elastomeric substrate using well-established ball indentation technique. Soft elastomeric nanopillars of height ranging from 50 nm to 500 nm are prepared. Finite element simulations are performed to understand the large deformation behaviour of the elastomer. Different parameters such as indenter diameter, the shape of the indenter and elastomer properties are considered to tune the nanopillar height and width. These high aspect ratio nanopillars on flat surfaces can find many potential applications in recent days. In particular, these nano-pillar surfaces can be efficiently applied in the biomedical fields such as cell mechanics studies and biosensors. In these studies, nanopillar devices are implemented as a means to study cell–substrate, and cell to cell interactions. The stiffness and the deflection characteristics of these nanopillars are extremely necessary for biomedical applications.

Keywords


Ball Indentation, Hyperplastic Membranes, Nanopillars, and Young’s Modulus.

References