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Chaudhari, Rajendra
- Study of Histopathological findings of Placenta in Cases of Deliveries at Tertiary Health Care Institute
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1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 4, No 2 (2017), Pagination: 165-171Abstract
Placentae from 67 mothers were studied, of which 28 were from mothers with uncomplicated pregnancies, and the remaining were associated with various maternal and fetal disorders. The purpose of this study was to describe the various gross and microscopic findings in the placentae, and to correlate them with various clinical and radiological abnormalities. Gross and microscopic examination of all the placentae was carried out. Formalin-fixed, paraffin-embedded tissue sections were used which were stained with hematoxylin and eosin. This study found a significant increase in neonatal weight, placental weight and placental diameter in cases of Gestational Diabetes Mellitus (GDM) as compared to cases of Normal Gestation (NG); while neonatal weight, placental weight and placental diameter were significantly lower in cases of maternal anemia, Pregnancy Induced Hypertension (PIH) and Intrauterine Growth Retardation (IUGR) as compared to cases of NG. This study found a significantly increased prevalence of calcifications, syncytial knots, infarcts and fibrinoid necrosis in cases of PIH as compared to cases of NG. Also, the prevalence of sclerotic villi, syncytial knots and chorangiosis was significantly more in cases of GDM than in cases of NG. In addition, the prevalence of sclerotic villi, syncytial knots, infarcts and fibrinoid necrosis was significantly more in cases of maternal anemia than in cases of NG. Overall, the study showed several significant findings, both gross and microscopic, in placentae from mothers and/or foetuses affected by various pathological processes. It was seen that conditions such as GDM, anemia, PIH etc. have a profound effect upon both the foetus and the placenta. Placental examination thus gives an idea of the type and severity of the condition complicating the pregnancy.Keywords
Anemia, Histopathology, Placenta, GDM, IUGR, PIH.References
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- Histopathological Evaluation of Carcinoma Breast with Significance of Histological Grading and Other Morphological Prognostic Factors at a Tertiary Health Care Institute
Abstract Views :166 |
PDF Views:112
Authors
Affiliations
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
1 Department of Pathology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 5, No 2 (2018), Pagination: 185-193Abstract
Background: Breast carcinoma is the second common malignancy among women. Pathological prognostic factors in breast cancer are now widely used to predict prognosis of breast carcinoma and to plan its effective management. Aim and Objectives: To analyze the spread and extent of various histological patterns of carcinoma breast, to do grading and staging of the tumors and to correlate above factors with the prognosis. Material and Methods: The present study was a prospective study of histopathological findings of modified radical mastectomy specimens received in the department of pathology of Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik over a period of 2 years and 3 months that is from June 2015 to September 2017. A total of 45 mastectomy specimens were analyzed in this period, using standard histopathology technique. Positive status of Axillary lymph nodes and other prognostic factors were analyzed. Nottingham Prognostic Index (NPI) was used to assess the prognosis. Follow up of all the patients was kept. Results: Out of 45 total cases, the most common histologic type was Invasive Ductal Carcinoma (NOS) (86.67%). The largest tumor size was 14.5cm. Maximum tumors were of Grade II. Out of the 45 cases, 31 (68.88%) cases showed tumor metastasis in axillary lymph nodes. 48.88% of the patients showed poor prognosis category with score greater than 5.4. Conclusion: After keeping follow up with the patients we came to a conclusion that, the lymph node status, tumor size, histologic pattern, histologic grade, necrosis and presence or absence of blood vessel invasion remains the best independent prognostic indicators.Keywords
Carcinoma Breast, Modified Bloom Richardson Score, Nottingham Prognostic Index, TNM Staging.References
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