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Phulkar, Sarita
- Comparison Between Propofol and Etomidate in General Anaesthesia as Induction Agents at a Tertiary Care Centre
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Authors
Affiliations
1 Professor and Head, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
2 Former PG Resident, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
3 Associate Professor, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
1 Professor and Head, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
2 Former PG Resident, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
3 Associate Professor, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 8, No 2 (2021), Pagination: 179-182Abstract
Aims: To compare hemodynamic changes occurring due to Propofol and Etomidate during general anesthesia as induction agents at a Tertiary Care Centre. Materials and Methods: 68 Adult ASA1 and ASA 2 Patients undergoing elective surgeries under gender anaesthesia in the department of Anaesthesia, Medical college and tertiary health care Centre after considering and satisfying the inclusion and exclusion criteria were selected and divided in two equal groups. They were given Propofol (2mg/kg) and Etomidate (0.3mg/kg) and hemodynamics were compared. Results: Etomidate was having more stable hemodynamic conditions as compared to Propofol induced anaesthesia. There was significant reduction in heart rate and blood pressure leading to hypotension in propofol group while etomidate group had stable hemodynamics. Conclusion: This study concludes that etomidate is a better agent for induction than propofol in view of hemodynamic stability.Keywords
Induction Agents, Hemodynamic Changes, Propofol, EtomidateReferences
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- Comparison of Intubating Conditions in Patients Induced with Succinylcholine, Atracurium and Priming with Atracurium
Abstract Views :166 |
PDF Views:99
Authors
Affiliations
1 Associate Professor, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422203, IN
2 Former PG Resident, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422203, Maharashtra, IN
1 Associate Professor, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422203, IN
2 Former PG Resident, Department of Anaesthesia, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422203, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 8, No 2 (2021), Pagination: 183-190Abstract
Background: This was a comparative observational study to compare the intubating conditions in patients posted for elective surgeries under general anaesthesia using succinylcholine, atracurium or priming with atracurium. Depolarizing muscle relaxant, frequently used for rapid sequence endotracheal intubation, has serious complications that occur intermittently, such as, hyperkalemia, increased intraoccular pressure and sudden cardiac arrest. So the priming principle, i.e., the administration of a subparalyzing dose of a nondepolarizing muscle relaxant (priming dose) prior to the intubating dose, was developed for rapid sequence endotracheal intubation with nondepolarizing muscle relaxant. This study compares the intubating conditions using a depolarizing muscle relaxant, a nondepolarizing muscle relaxant and priming with a nondepolarizing muscle relaxant. Methodology: Total 114 patients scheduled for elective surgeries were allocated into 3 groups. We assessed the intubating conditions with jaw relaxation, position of vocal cords, response to intubation (coughing, straining or muscular movements), haemodynamic response to intubation and number and strength of twitches to train of four stimuli just before intubation. Results: All the patients in different study groups were comparable in terms of age, sex, ASA status. The mean SBP, DBP was statistically significantly higher in Group B as compared to Group C group and Group A from 1 minute after intubation till after extubation. Good jaw relaxation was most commonly observed in group A (100%) as compared to group C (31%) and group B (17.5%) and the difference was statistically significant. Open vocal cord was most commonly observed in group A (100%) as compared to group C (75%) and group B (23%) and the difference was statistically significant. Severe coughing was most commonly observed in group B (17.5%) as compared to group C (0%) and group A (0%) and the difference was statistically significant. Severe muscular movements was most commonly observed in group B (21%) as compared to group C (0%) and group A (0%) and the difference was statistically significant.1,2,3 twitch was most commonly observed in group B (100%) as compared to group C (77.5%) and group A (56%) and the difference was statistically significant. Increase in BP and pulse > 20% of basal values was most commonly observed in group B (42%) as compared to group C (0%) and group A (0%) and the difference was statistically significant. Excellent to good scoring was most commonly observed in group A (100%) as compared to group C (92.5%) and group B (25%) and the difference was statistically significant. Conclusion: Succinylcholine is still the ideal choice for rapid sequence induction. Priming with atracurium can be used as an efficient alternative when succinylcholine is contraindicated.Keywords
Succinylcholine, Atracurium, Intubation, Muscle Relaxant, Elective SurgeryReferences
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