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Kumavat, Shrikant
- Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute
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PDF Views:75
Authors
Affiliations
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
1 Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra, IN
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MVP Journal of Medical Sciences, Vol 5, No 2 (2018), Pagination: 211-215Abstract
Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerbation of psoriasis. Serum alkaline phosphatase level is a marker of oxidative stress in body. Aims and Objectives: To study and compare serum alkaline phosphatase levels in cases of psoriasis. Materials and Methods: Serum Alkaline Phosphatase levels were evaluated in 100 cases of psoriasis and controls. Results: There was no statistically significant difference between serum alkaline phosphatase levels among cases and controls. Conclusion: Serum alkaline phosphatase levels, as a marker of oxidative stress is not significantly raised in cases of psoriasis.Keywords
Alkaline Phosphatase, Oxidative Stress, Psoriasis.Full Text
References
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- Malligarjunan H, Gnanaraj P, Subramanian S, Elango T, Dayalan H. Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients, Clin. Biochem. 2011 Oct; 44(14-15):1209−13. Epub. 2011 Jul 28. https://doi.org/10.1016/j.clinbiochem.2011.07.009.
- Smith AE, Kassab JY, Rowland Payne CME, Beur WE. Bimodality in age of onset of psoriasis in both patients and relatives, Dermatology. 1993; 186:181−86.
- Pavithran K, Karunakaran M, Aparna P, Raghunatha S. PsoariasisIn: Valia RG, Valia AR. EDS. Disorders of keratinization. IADVL textbook of dermatology. Third edition. Volume 1, reprint. Bhalani publishing house; 2012. 30, p. 1021−56.
- Gudjonsson JE, Elder JT. Psoriasis. In: Goldsmith LA, Katz SI, Gilchrest, Paller AS, Leffell DJ, Wolff K. Eds. Fitzpatrick Dermatology in General Medicine. Eighth edition. Volume I; 2008. 18, p. 197−231.
- Griffiths CEM, Barker JNWN. Psoriasis In: Tony B, Stephen B, Neil C, Christopher G. editors. Rook textbook of dermatology, Eighth edition. Volume 1, Wiley-Blackwell; 2010. 20, p. 1−20.
- Peter Cm, Kerkhof vd, Nestle FO. Psoriasis In: Bolognia JL, Jorizzo JL, Schaffer JV, Eds. Dermatology, Third edition. Elsevier; 2008. p. 135−56.
- Smith CH, Anstey AV, Barker JN et al. British Association of Dermatologists guidelines for use of biological intervention in psoriasis, Br J Dermatol. 2005; 153:486−97.
- David H. Vroon, Zafar Israili. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd Edition.
- Oxidative Medicine and Cellular Longevity. 2016 (2016). Article ID 8490643, p. 7.
- Bhatnagar M, Bapna A, Khare A K. Serum proteins, trace metals and phosphatases in psoriasis, Indian J. DermatolVenereol. Leprol. 1994; 60:18−2
- Franck H, Ittel T. Serum osteocalcin levels in patients with psoriatic arthritis: An extended report, Rheumatol Int. 2000; 19(5):161−4
- Nestle FO et al. Skin immune sentinels in health and disease, Nat. Rev. Immunol. 2009; 9(10):679−91.
- Sheikh G, Masood Q, Majeed S, Hassan I. Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based case control study, Indian Dermatol. Online J. 2015 Mar-Apr; 6(2):81−3. https://doi.org/10.4103/2229-5178.153006.
- Enerback C, Martinsson T, Inerot A, Wahlstrom J, Enlund F, Yhr M, Swanbeck G. Evidence that HLA-cw6 determines early onset of psoriasis, obtained using sequence-specific primers (PCR-SSP), Acta. Dermatovenerologica. 1997; 77(4):273−76.
- Cohen A D, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh D Y, Vardy D A. Psoriasis and the Metabolic Syndrome. ActaDermVenereol 2007; 87: 506–509. https://doi.org/10.2340/00015555-0297.
- Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgar is and the relation between disease severity and metabolic syndrome: A hospital-based case-control study, Indian J. Dermatol. 2012; 57:353−7.
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- A Clinical and Histopathological Correlation among Leprosy Patients (in this Post Elimination Era) Attending Tertiary Referral Centre
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PDF Views:104
Authors
Affiliations
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
1 PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Associate Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Institute of Medical Sciences and Research, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 6, No 2 (2019), Pagination: 103-108Abstract
Background: Leprosy is caused by Mycobacterium leprae, which chiefly affect skin and peripheral nerves. Leprosy expresses itself in different clinicopathological forms depending upon underlying immunity of the host. Histopathology is considered gold standard for accurate diagnosis especially in early disease, however, clinicopathological correlation is a must for appropriate diagnosis and classification of disease that will in-turn affect the treatment and overall prognosis of the patient. The present study of clinicohistopathological correlation among leprosy patients in this post elimination era was undertaken. Aims and Objectives: To study the clinical and histopathological correlation among leprosy patients. Materials and Methods: Present study consists of 54 patients of newly diagnosed leprosy cases at Department of Dermatology, Venerology and Leprology from November 2016 to October 2018. Skin punch biopsy and slit skin smear taken from patients. Histopathological examination by staining with H&E and Fite-Faraco stain for tissue AFB and Ziehl-Neelsen staining of SSS for presence of AFB. Results: In this study, 35 cases (64.81%) showed clinicohistopathological concordance and 19 cases (35.19 %) were discordant according to Ridley-Jopling spectrum. Conclusion: Histology should be performed in all suspected patients of leprosy if feasible, for exact allocation of the patient across the spectrum for accurate treatment and to identify the vulnerable patients in borderline spectrum as they are prone for reactions, neuritis and thus deformities and it also aids in achieving terminal goal of leprosy elimination.Keywords
Clinicohistopathological Concordance, Leprosy, Ridley-Jopling Classification.Full Text
References
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- Sengupta U. Leprosy: Immunology. In: Valia RG and Valia AR. IADVL Textbook and Atlas of Dermatology, 2nd edn. Mumbai. Bhalani Publishing House. 2001: 1573.
- Ridley DS, Jopling WH. Classification of leprosy according to immunity: a five group system. Int. J. Lep. 1996; 34(3): 255–77.
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- Nayak SV, Shivarudrappa AS, Nagarajapa AH, Ahmed SM. Role of modified rapid AFB method in Histopathological sections of Hansen’s disease. Ind. J. Dermatol Venereol Leprol. 2003; 69: 173–74.
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- Gupte MD, Manickam P. Leprosy: Epidemiology. 3rd ed. In: IADVL Textbook of Dermatology, Valia RG, Valia AR, eds. Mumbai: Bhalani Publishers; 2008. 1994–2004.
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- Ankur Kumar, S. R. Negi, Kusum Vaishnav, A study of Clinicohistopathological correlation of leprosy in a tertiary care hospital in western district of Rajasthan. Journal of Research in Medical and Dental Science. 2014; 2(3): 43–48. https://doi.org/10.5455/jrmds.20142310.
- Bijjaragi S,V Kulkarni , KK Suresh , KR Chatura , P Kumar, Correlation of clinical and histopathological classification of Leprosy in post elimination era, Indian J Lepr. 2012; 84: 271–275.
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- Mathur MC, Ghimire RBK, Shrestha P, Kedia SK. Clinicohistopathological Correlation in Leprosy. Kathmandu Univ Med J. 2011; 36(4): 248–51. https://doi.org/10.3126/kumj.v9i4.6338.
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- Bhatia AS, Katoch Kiran, Narayanan RB, Ramu Gopal, Mukherjee Ashok, Lavania RK: Clinical and Histopathological Correlation in the Classification of Leprosy. Int. J. Lepr. 1993; 61(3): 433–438.
- Study of Skin Diseases in Incumbent Prison Inmates
Abstract Views :263 |
PDF Views:81
Authors
Affiliations
1 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital & Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
2 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
1 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital & Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
2 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 7, No 2 (2020), Pagination: 277-281Abstract
Introduction: Dermatological diseases in prison is still an under-researched field and the importance of identifying and treating them promptly has recently been recognized. Skin diseases are common among prisoners especially those from developing countries due to the substandard living conditions such as overcrowding with hot and humid environment. Aims and Objectives: Our study aimed to estimate the occurrence of various dermatological diseases among prison inmates. Materials and Methods: A descriptive cohort study of inmates at Nashik Central Jail, Maharashtra was done for a duration of 6 months between February to July 2018. Results: Out of 3609 inmates, 532 inmates (461 males and 71 females) aged 23–62 years were suffering from various skin diseases. Most common skin disease were infectious dermatoses (72.18%, n=384). Amongst infections, fungal contributed to maximum cases (85.93%, n=330) of cases followed by bacterial infection (13.84%, n=53). Infestations were second most common skin disease (20.86%, n=111). Rest were less 7% of cases. Conclusion: Prison inmates are prone to develop various skin infections and infestations due to poor standard of living. They are often neglected & may pose a danger of spreading skin infections among other prison inmates & in the community eventually. Appropriate and adequate health policies can prevent skin disease in prison.Keywords
Eczema, Papulosquamous, Infection, Infestation, Prison, Skin DiseasesFull Text
References
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- Unresponsive Alopecia Areata Treated Successfully with Liquid Nitrogen Cryotherapy: A Study of Five Patients
Abstract Views :260 |
PDF Views:56
Authors
Affiliations
1 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital and Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
1 Professor and Head, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik - 422003, Maharashtra, IN
2 Former PG Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College and Hospital and Research Centre, Adgaon, Nashik – 422003, Maharashtra, IN
3 Assistant Professor, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
4 Senior Resident, Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College Hospital and Research Centre, Nashik – 422003, Maharashtra, IN
Source
MVP Journal of Medical Sciences, Vol 7, No 2 (2020), Pagination: 288-294Abstract
Introduction: Alopecia Areata (AA) is one of the most common form of hair loss seen in dermatology. Treatment failures can occur with almost every conventional therapy, either singly or in combination. Aims and Objectives: To study the clinical profiles and management outcome of Liquid Nitrogen Cryotherapy (LNC) for the treatment of unresponsive cases of AA. Materials and Methods: A prospective study was conducted on five patients who showed no response to conventional topical treatment for six months. The subjects were enrolled in the study after written consent. Clinical photographs were recorded at each visit. Patients were given 3-5 sittings of LNC at 2 week intervals. Each session consisted of dual freeze thaw cycles of 15 seconds each, with a cryospray technique following application of topical anaesthetic cream. Suitable antibiotics and anti-inflammatory agents were prescribed post-operatively for five days. The clinical response was evaluated by using regrowth scale at 4th week and 8th week. Final end point evaluation of patient post 3 months after the last treatment session was done to observe sustained regrowth of hair. Results: Five patients were recruited, out of which three patients showed an excellent response, 1 each had a satisfactory response and a fair response respectively. Commonly seen adverse effects were slight pain, erythema, edema, erosion, crusting, dyspigmentation/hypopigmentation, which were transient and did not require withdrawal of treatment. Conclusion: Liquid Nitrogen Cryotherapy is a cheaper, easily available with transient adverse effects and can be worth trying in unresponsive Alopecia Areata.Keywords
Alopecia Areata(AA), Liquid Nitrogen Cryotherapy (LNC), UnresponsiveFull Text
References
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