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Solvent Free Synthesis and Biological Evaluation of 1, 5-Benzodiazepine


Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, 413736, India
2 Department of Pharmaceutical Chemistry, SRES’s Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, 423601, India
 

Number of substituted 1, 5-benzodiazepines are known for their biological importance like anti-bacterial, antifungal, anticancer, and anti-inflammatory activity. The present investigation is carried for the synthesis of certain substituted 1, 5-benzodiazepines and carried out their sedative activity. The title compounds have been synthesized from OPD reacts with substituted aryl aldehydes to give substituted 1, 5-benzodiazepines. The newly synthesized compounds have been characterized by IR, 1H NMR and CHN analysis. Selected compounds are screened for sedative activity in vivo using spontaneous locomotor activity model. Few of them exhibited promising activity.

Keywords

1, 5-Benzodiazepines, Pharmacological Screening, Sedative Activity, Spontaneous Locomotor Activity, IR, 1H NMR, CHN Analysis.
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  • Solvent Free Synthesis and Biological Evaluation of 1, 5-Benzodiazepine

Abstract Views: 210  |  PDF Views: 4

Authors

S. D. Nachiket
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, 413736, India
K. W. Atul
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS, 413736, India
S. M. Deepak
Department of Pharmaceutical Chemistry, SRES’s Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, 423601, India

Abstract


Number of substituted 1, 5-benzodiazepines are known for their biological importance like anti-bacterial, antifungal, anticancer, and anti-inflammatory activity. The present investigation is carried for the synthesis of certain substituted 1, 5-benzodiazepines and carried out their sedative activity. The title compounds have been synthesized from OPD reacts with substituted aryl aldehydes to give substituted 1, 5-benzodiazepines. The newly synthesized compounds have been characterized by IR, 1H NMR and CHN analysis. Selected compounds are screened for sedative activity in vivo using spontaneous locomotor activity model. Few of them exhibited promising activity.

Keywords


1, 5-Benzodiazepines, Pharmacological Screening, Sedative Activity, Spontaneous Locomotor Activity, IR, 1H NMR, CHN Analysis.

References