An Intelligent System for the Characterization of Hyperlipidemic Blood and a Comparative Study on the Efficacy of Statins

Elevated lipid level is supposed to be one of the main risk factors for cardiovascular diseases. Therefore lipid lowering is one of the major target in cardiovascular treatment and prevention. Hence hyperlipidemic blood has to be identified and lipid level has to be lowered. Atorvastatin and simvastatin are the lipid lowering agents, they lower the low density cholesterol. For the characterization of hyperlipidemic blood, the FTIR spectra of blood sera of 20 healthy people and 20 hyperlipidemic patients of the same age group were recorded and fed as input to our system.To study the efficacy of statins, the FTIR spectral data of blood sera of the 20 hyperlipidemic patients of the same age group and blood group were recorded and fed as input to our system. Our system is trained to distinguish between the healthy and hyperlipidemic blood. Some remarkable differences are identified by our system. Both the statins were well tolerated and it is concluded from the results that Atorvastatin is more efficacious than simvastatin in modifying lipids in patients with hyperlipidemia and a high coronary heart disease risk. FTIR spectroscopy allows accurate lipids concentration determination. The results obtained from our System are well supported by both spectroscopic data and clinical data. Since our system is trained to distinguish the hyperlipidemic blood with the fine details of FTIR spectra, it can improve the diagnostic accuracy and rate of cardiovascular treatment and also it can analyze the efficacy of statins at a faster rate with more accuracy.